浙江医学2018，Vol.40Issue(8)：833-835,3.DOI:10.12056/j.issn.1006-2785.2017.40.8.2018-27
IL-1Ra在炎症性肠病患者血清中的表达及临床意义
Serum IL-Ra levels in patients with inflammatory bowel disease and its clinical significance
摘要
Abstract
Objective To investigate serum levels of IL-1 receptor antagonist (IL-Ra) in patients with inflammatory bowel disease (IBD) and its clinical significance.Methods Seventy one IBD patients,including 34 cases of crohn disease (CD) and 37 cases of ulcerative colitis (UC),were recruited in Zhejiang Hospital from January 2016 to December 2016,and 49 healthy subjects (control group) were also included in the study.ELISA was applied to detect the serum IL-Ra levels in patients and healthy individuals.Results The serum levels of IL-Ra in UC,CD and control groups were (5.16 ± 0.83) pg/ml,(4.13 ± 0.64) pg/ml and (1.86 ± 0.17) pg/ml,respectively (P＜0.01).Serum IL-Ra levels in UC and CD patients were increased with disease activity increasing,(P＜0.01).Conclusion Serum IL-Ra levels are significantly increased in IBD patients as compared to healthy individuals,and it may be a promising indicator for assessing IBD disease activity.关键词
炎症性肠病/溃疡性结肠炎/克罗恩病/IL-RaKey words
Inflammatory/Ulcerative colitis/Crohn disease/Interleukin-1 receptor antagonist引用本文复制引用
冯玉良,何巧娜,周锋,朱琴,王卫峰,郑培奋..IL-1Ra在炎症性肠病患者血清中的表达及临床意义[J].浙江医学,2018,40(8):833-835,3.基金项目
浙江省自然科学基金项目(Y17H030031) （Y17H030031）
