浙江医学2018，Vol.40Issue(8)：836-838,847,4.DOI:10.12056/j.issn.1006-2785.2017.40.8.2017-788
肺泡灌洗液Xpert MTB/RIF检测在涂阴肺结核早期诊断中的应用价值
Detection of Xpert MTB/RIF in bronchoalveolar lavage fluid for diagnosis of smear-negative pulmonary tuberculosis
摘要
Abstract
Objective To evaluate the detection of Xpert MTB/RIF in bronchoalveolar lavage fluid (BALF) for the early diagnosis of smear-negative pulmonary tuberculosis.Methods The BALF samples were obtained from 157 cases of smear negative pulmonary tuberculosis (study group) and 56 non-pulmonary tuberculosis patients (control group).The acid fast staining,mycobacterium liquid culture and Xpert MTB/RIF detection in BALF were performed in two groups,and the positive rates of three detection methods in study group were compared.Results The Xpert MTB/RIF positive rate in BALF of study group was significantly higher than that of control group (73.9％ vs.1.8％,P ＜0.05).The positive rates of anti acid staining smear,mycobacterium liquid culture and Xpert MTB/RIF in the study group were 20.4％,38.9％ and 73.9％,respectively (P＜0.05).With the mycobacterium liquid culture drug sensitivity test as the gold standard,the sensitivity and specificity of Xpert/MTB/RIF for detection of resistance to rifampin was 100.0％ and 98.0％,respectively.Conclusion The detection of Xpert MTB/RIF in bronchoalveolar lavage fluid has high sensitivity and specificity in diagnosis of smear-negative pulmonary tuberculosis.关键词
肺结核/肺泡灌洗液/Xpert MTB/RIF检测Key words
Pulmonary tuberculosis/Bronchoalveolar lavage fluid/Xpert MTB/RIF detection引用本文复制引用
钟剑峰,童涌,童照威,宋群,王伟洪..肺泡灌洗液Xpert MTB/RIF检测在涂阴肺结核早期诊断中的应用价值[J].浙江医学,2018,40(8):836-838,847,4.基金项目
湖州市科技局公益性重点科技计划项目(2014GZ10) （2014GZ10）
