摘要
Abstract
Objective To investigate the analgesic effect of hytromorphone hydrochloride and serum levels of stress-related hormones in breast cancer patients with chemotherapy.Methods Sixty six advanced breast cancer patients with chemotherapy were randomly divided into 2 groups with 33 in each group:patients in study group received hydromorphone hydrochloride for analgesia and patients in control group received disodium pamidronate.The VAS,KPS score and serum 5-HT,NO,PGE2,Cor,GH and PRL levels were measured before and 1,2,4 months after treatment.Results The VAS and KPS scores of study group were significantly higher than those of control group(Z=6.79,P＜0.05;Z=7.10,P＜0.05).The serum levels of 5-HT,NO,PGE2,Cor,GH and PRL at 1,2 and 4 months after treatment were significantly lower than those before treatment in both groups (P＜0.01 or P＜0.05);while the levels in study groups after treatment were lower than those in control group (P＜0.05).Spearman analysis revealed a negative correlation between VAS,KPS scores and stress-related hormone levels(VAS:r=-0.824,-0.855,-0.738,-0.766,-0.825,-0.879;KPS:r =-0.788,-0.844,-0.865,-0.792,-0.815,-0.873,all P＜0.05).Conclusion Hydromorphone hydrochloride is more effective than disodium pamidronate in analgesia for advanced breast cancer patients with chemotherapy,which is associated with the inhibition of serum stress-related hormones levels.关键词
盐酸氢吗啡酮/疼痛相关激素/乳腺癌Key words
Hydromorphone hydrochloride/Stress-related hormone/Breast cancer
