肿瘤药学2018，Vol.8Issue(2)：143-147,5.DOI:10.3969/j.issn.2095-1264.2018.02.04
阿霉素偶联氧化锌量子点的制备及其对肺癌A549细胞增殖抑制作用的研究
The Study of Doxorubicin Coupled ZnO QDs on the Inhibition of Lung Cancer A549 Cells Proliferation
摘要
Abstract
Objective To develop ZnO quantum dots (QDs) loading doxorubicin which has lower toxicity and higher effect on anti-tumor treatment. Methods The drug-loaded QDs were prepared by coupling ZnO QDs with Doxorubicin through TK linker, and were confirmed by DLS, FT-IR and zeta potential. Finally the anti-proliferation activities of doxorubicin-ZnO QDs against lung cancer A549 cells were evalu-ated by MTT assay. Results The doxorubicin-ZnO QDs were prepared and showed good efficiency of killing A549 tumor cells. Conclusions The doxorubicin-ZnO quantum dots could release the drug in A549 tumor cell and have the potency of developing into a new anticancer drug delivery system in vivo.关键词
ZnOQDs/阿霉素/A549细胞/抗肿瘤Key words
ZnO quantum dots/Doxorubicin/A549 cells/Antitumor分类
医药卫生引用本文复制引用
巩亚翔,牛一民,侍慧慧,朱建华,李阳,刘阳,徐群为..阿霉素偶联氧化锌量子点的制备及其对肺癌A549细胞增殖抑制作用的研究[J].肿瘤药学,2018,8(2):143-147,5.基金项目
国家自然科学基金项目(81273457). （81273457）
