肿瘤药学2018，Vol.8Issue(2)：162-169,8.DOI:10.3969/j.issn.2095-1264.2018.02.08
调强适形放疗与同步放化疗应用于食管癌患者的疗效比较研究
A Comparative Study between Intensity Modulated Radiation Therapy and Combined Radio-chemotherapy for Treatment of Esophagus Cancer Patients
袁倩倩 1张开贤 1江萍 2王俊杰 2邢超 1张旭升 1胡苗苗 1满其荣1
作者信息
- 1. 滕州市中心人民医院 肿瘤科,山东 滕州,277599
- 2. 北京大学第三医院 放疗科,北京,100083
- 折叠
摘要
Abstract
Objective Retrospective analysis of intensity modulated radiation therapy (IMRT) and combined radio-chemotherapy for treat-ment of esophageal cancer patients. Methods Retrospective analysis of 186 esophageal cancer patients' clinical data that accepted IMRT in our department from February 2011 to December 2013.106 esophageal cancer patients were treated with combined radio-chemotherapy and 80 esophageal cancer patients were treated with intensity modulated radiation therapy. Compare the survival situation and toxic reaction between the two groups. Results Until May 12, 2015, all patients' follow-up rate was 97.8%. Total survival rates of 1-, 2-, 3-year in two groups were 60.1%, 36.3%, 31.5% respectively, the median survival time was 16 months (95% CI: 12.9~19.1). Total survival rates of 1, 2, 3-year in com-bined radio-chemotherapy group were 68.2%, 44.5% and 37.3% respectively, the median survival time was 21 months. Total survival rates of 1-, 2-, 3-year in radiation therapy alone group were 49.3%、26.1%、24.1% respectively, the median survival time was 12 months, the difference was significant (x2=6.151, P=0.013). There were significant differences in the total survival and progression-free survival rate of N1 stage between the two groups (x2=6.164/6.869, P=0.013/0.009). There were also significant difference in total survival rate of M1a stage between the two groups (x2=5.635, P=0.018). The toxic reaction incidence of combined radio-chemotherapy group was higher than radiation therapy alone, mainly including decrease of platelets, white blood cells and hemoglobin (P=0.030/0.036/0.095). Conclusion Compared with radiation therapy alone, combined radiation and chemotherapy can improve the survival rate of esophageal cancer patients, especially for patients of N1 and M1a stage. The toxic reaction incidence of combined radiochemotherapy group was higher, but all were tolerated.关键词
食管癌/调强适形放疗/联合放化疗Key words
Esophagus cancer/Combined radio-chemotherapy/Intensity modulated radiation therapy分类
医药卫生引用本文复制引用
袁倩倩,张开贤,江萍,王俊杰,邢超,张旭升,胡苗苗,满其荣..调强适形放疗与同步放化疗应用于食管癌患者的疗效比较研究[J].肿瘤药学,2018,8(2):162-169,8.
