肿瘤药学2018，Vol.8Issue(2)：198-202,5.DOI:10.3969/j.issn.2095-1264.2018.02.16
表柔比星联合环磷酰胺治疗乳腺癌改良根治术后患者的疗效分析
Clinical Efficacy of Epirubicin Combined with Cyclophosphamide for treatment of the Patients with Breast Cancer after Modified Radical Surgery
付小杰 1张凯松 1徐冰理 1苏涛锋 1王长璐1
作者信息
- 1. 北京中医药大学第三附属医院 普外科,北京,100029
- 折叠
摘要
Abstract
Objective To study the effect of epirubicin and cyclophosphamide combination chemotherapy on the efficacy and survival rate for breast cancer patients after modified radical mastectomy Methods 86 patients with breast cancer were treated by modified radi-cal mastectomy for breast cancer patients from February 2013 to April 2014 in our hospital. They were randomly divided into observation group and control group, 43 cases in each group. The patients in control group were treated with docetaxel combined with epirubicin, and the patients in observation group application of epirubicin and cyclophosphamide combination respectively. The clinical efficacy, the index of operation level, the incidence of adverse reaction of the two groups between 1 and 3 years survival rate were analyzed. Results The total effective rate of patients in observation group was 95.35%, significantly higher than that in control group (67.44%) (P<0.05). The hospitali-zation time of patients in the observation group was (3.3±0.5) d, there was no significant difference compared with that in the control group [ (7.1±1.4) d] (P<0.05). The occurrence rates of neutropenia, nausea and vomiting in observation groups were 74.42%, 51.16%, which were significantly decreased compared with those in the control group (100.00%, 79.07%) (P<0.05). The observation group 3-year survival rate was 86.05%, and in the control group was 67.44%, the difference was statistically significant (P<0.05). Conclusion The application of epirubicin in modified radical mastectomy is better for patients with breast cancer, and it can improve the safety and survival rate of patients.关键词
乳腺癌/表柔比星/环磷酰胺/疗效/生存率Key words
Breast cancer/Epirubicin/Cyclophosphamide/Curative effect/Survival rates分类
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付小杰,张凯松,徐冰理,苏涛锋,王长璐..表柔比星联合环磷酰胺治疗乳腺癌改良根治术后患者的疗效分析[J].肿瘤药学,2018,8(2):198-202,5.
