肿瘤药学2018，Vol.8Issue(2)：203-207,5.DOI:10.3969/j.issn.2095-1264.2018.02.17
FOLFOX辅助化疗对中晚期老年直肠癌患者肿瘤标记物、免疫功能及生活质量的影响
The Influence of FOLFOX Adjuvant Chemotherapy on Tumor Markers, the Immune Function, and the Life Quality of Aged Patients with Middle-late Colorectal Cancer
苑汐子 1党长宁 1孙凤伟 1王永 1张喻然1
作者信息
- 1. 辽宁中医药大学附属三院 肛肠五科,辽宁 沈阳,110000
- 折叠
摘要
Abstract
Objective To explore the FOLFOX adjuvant chemotherapy on the immune function of aged middle-late colorectal tumor markers, and the influence of the quality of life. Methods 80 patients with advanced rectal cancer were divided into two groups from January 2012 to December 2012 in our hospital, 40 cases for each group. Patients in the observation group were given FOLFOX scheme, and those in the control group with FOLFIRI scheme. All patients had one year outpatient follow-up. The CEA and CA-199 level, the humoral immune globulin level after intervention, quality of life score, clinical effect, and 1-year survival situation of patients between the two groups were compared before and after the intervention. Results After intervention, CEA and CA-199 of patients were significantly lower than those be-fore intervention in the two groups (P<0.05). The CEA and CA-199 levels of patients in the observation group were significantly lower than in the control group after intervention (P<0.05). The postoperative IgM and IgG and IgA levels of patients in the observation group were higher than in the control group (P<0.05). Besides, the quality of life score of patients were better than that before in both groups after inter-vention (P<0.05). The quality of life of patients in the observation group was better than that in the control group after intervention (P<0.05). The effectiveness of patients in the observation group was significantly higher than that in the control group (P<0.05). The 3 months, 6 months and 1 year survival rates of patients in the observation group were also significantly higher than that in the control group. Conclu-sion FOLFOX middle-late adjuvant chemotherapy regimen for patients with rectal cancer, brain function effectively reduces the body tumor marker levels, improves immune ability, the quality of life, the effect of clinical treatment, and the survival time.关键词
FOLFOX辅助化疗/中晚期直肠癌/肿瘤标记物/免疫功能Key words
FOLFOX adjuvant chemotherapy/Middle-late colorectal cancer/Tumor markers/Immune function分类
医药卫生引用本文复制引用
苑汐子,党长宁,孙凤伟,王永,张喻然..FOLFOX辅助化疗对中晚期老年直肠癌患者肿瘤标记物、免疫功能及生活质量的影响[J].肿瘤药学,2018,8(2):203-207,5.
