肿瘤药学2018，Vol.8Issue(2)：208-210,235,4.DOI:10.3969/j.issn.2095-1264.2018.02.18
不同剂量二甲双胍对有生育要求的早期子宫内膜癌患者的疗效及其机制
Efficacy and Mechanism of Different Doses of Metformin on Early Endometrial Cancer Patients with Fertility Requirements
摘要
Abstract
Objective To explore the mechanism of metformin in the improvement of early endometrial cancer patients with reproductive requirements by regulating the PI3K/AKT signaling pathway. Methods 90 early endometrial cancer patients with fertility requirements in our hospital were selected and they were randomly divided into research group and control group. The patients in the two groups were treated with metformin drugs of high and low concentration respectively. PTEN gene expression level and the content of PIP2 and IP3 were compared between the two groups before and after treatment. Treatment satisfaction, disease treatment efficiency, and the recurrence rate of patients in the two groups were compared after 3, 6, 9 months of treatment respectively. Results In the research group, the effective rate and treatment satisfaction both were significantly higher than those of the control group (P<0.05). Three months of treatment later, the recurrence rate of the disease of the research group was significantly lower than that of the control group (P<0.05). PTEN gene expression level and the increase of IP3 content of patients in the research group after treatment was significantly greater than those in the control group. Yet the decrease of PIP2 content was greater in the research group than in the control group (P<0.05). Conclusion Boosting the concentration of metformin appropri-ately can significantly improve the treatment efficiency of endometrial carcinoma in the early stage, reduce the incidence of adverse reactions in patients, and increase the expression level of tumor suppressor genes and the PIP2 conversion to IP3. It is of high clinical significance.关键词
二甲双胍/PI3K/AKT信号通路/早期子宫内膜癌/抑癌基因Key words
Metformin/PI3K/AKT signaling pathway/Early endometrial carcinoma/Tumor suppressor gene分类
医药卫生引用本文复制引用
冯绣梅,谭爱丽,龙平,王婷婷,杨菁..不同剂量二甲双胍对有生育要求的早期子宫内膜癌患者的疗效及其机制[J].肿瘤药学,2018,8(2):208-210,235,4.基金项目
湖北省卫生和计划生育委员会科研项目(WJ2015MB207) （WJ2015MB207）
湖北省自然科学基金面上项目(2015CFC827) （2015CFC827）
荆门市一般科研项目(YFYB2016010). （YFYB2016010）
