肿瘤药学2018，Vol.8Issue(2)：254-257,4.DOI:10.3969/j.issn.2095-1264.2018.02.30
As2O3联合全反式维甲酸对成分输血的急性白血病儿童免疫蛋白的影响及其疗效分析
The Effect and Influence on Immunoglobulins of As2O3 Combined with All-trans Retinoic Acid in the Treatment of Children with Acute Leukemia after Component Blood Transfusion
解广莹 1刘凤华 1曹荣祎 1赵琳琳 1卢东赫1
作者信息
- 1. 哈尔滨医科大学附属第一医院输血科,黑龙江 哈尔滨,150000
- 折叠
摘要
Abstract
Objective To explore the effect and its regulation of immunoglobulins of As2O3combined with all-trans retinoic acid in the treatment of acute leukemia children after transfusion. Methods 160 children with acute leukemia after transfusion were enrolled in this study in our hospital between Oct 2013 and Oct 2017. The effect of As2O3combined with all-trans retinoic acid in the treatment of acute leukemia children after transfusion and its regulation of immunoglobulin were assayed. Acute leukemia children in the control group were given As2O3or all-trans retinoic acid. Results As2O3combined with all-trans retinoic acid showed better effect on acute leukemia children than As2O3or all-trans retinoic acid alone with statistical differences (P<0.05). And the concentrations of IgA, IgM, Caspase3, and Cas-pase9 were decreased greatly after As2O3combined with all-trans retinoic acid treatment (P<0.05). Conclusion As2O3combined with all-trans retinoic acid is effective for the treatment of acute leukemia children after transfusion and can regulate immunoglobulin concentration.关键词
三氧化二砷/全反式维甲酸/急性白血病/免疫蛋白/细胞凋亡Key words
As2O3/All-trans retinoic acid/Acute leukemia/Immunoglobulin/Apoptosis分类
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解广莹,刘凤华,曹荣祎,赵琳琳,卢东赫..As2O3联合全反式维甲酸对成分输血的急性白血病儿童免疫蛋白的影响及其疗效分析[J].肿瘤药学,2018,8(2):254-257,4.
