肿瘤药学2018，Vol.8Issue(2)：263-267,5.DOI:10.3969/j.issn.2095-1264.2018.02.32
不同铂类药物联合调强放疗治疗中晚期NSCLC患者的血清肿瘤标志物水平及疗效观察
The Effect of Two Platinum Drugs Combined with Intensity Modulated Radiotherapy on Serum Tumor Markers and Clinical Efficacy for Patients with Advanced NSCLC Level
摘要
Abstract
Objective To study the effects of different platinum chemotherapy regimens combined with intensity modulated radiotherapy on the serum tumor marker levels and efficacy for advanced non-small cell lung cancer (NSCLC) patients. Methods A total of 118 patients with advanced NSCLC lung cancer were enrolled in department of oncology and radiotherapy in our hospital. They were randomly divided into group A and group B, 59 cases for each group. The patients in group A were given nedaplatin combined with intensity modulated ra-diotherapy, and those in group B were given cisplatin combined with three dimensional conformal radiotherapy. The levels of serum tumor markers, clinical efficacy, differences in toxicity and survival rate were compared between the two groups. Results The total effective rates of patients in group A and B were 89.83% and 81.36% respectively. The quality of life was significantly improved in the two groups after treat-ment, but it had no significant difference between the two groups (P>0.05). After treatment, the levels of CAE, SCC-Ag, CYFRA21-1 and TK1 in the two groups were decreased significantly compared with those before treatment (P<0.05). After treatment, the levels of SCC-A and TK1 of patients in group A were significantly lower than in group B (P<0.05). The incidences of side reactions like nausea, vomiting and renal impairment in group A was significantly lower than in group B, and it had statistical differences between the two groups (P<0.05). Conclusion Nedaplatin had equivalent efficacy to cisplatin in the treatment of patients with late NSCLC. It also had lower levels of tumor markers of patients and lower incidences of toxicity and side effects. So the patients in nedaplatin group were highly tolerated.关键词
非小细胞肺癌/调强放疗/奈达铂/肿瘤标志物Key words
Non-small cell lung cancer/Intensity modulated radiotherapy/Nedaplatin/tumor markers分类
医药卫生引用本文复制引用
节阳华,朱艳华,曾凡业,马全海,王宁..不同铂类药物联合调强放疗治疗中晚期NSCLC患者的血清肿瘤标志物水平及疗效观察[J].肿瘤药学,2018,8(2):263-267,5.基金项目
新疆自治区自然基金(2012211A094). （2012211A094）
