波谱学杂志2018，Vol.35Issue(2)：188-197,10.DOI:10.11938/cjmr20172601
在体检测γ-氨基丁酸的MEGA-PRESS序列优化设计
Optimization of the MEGA-PRESS Sequence for Detection of γ-Aminobutyric Acid in Vivo
摘要
Abstract
Abnormal metabolism γ-aminobutyric acid (GABA) is involved in many brain diseases, and in vivo GABA detection is important for the diagnosis of these diseases. This study optimized a commonly used spectral editing method for in vivo GABA detection, MEGA-PRESS. We used high-performance Shinnar-Le Roux (SLR) pulses to replace the commonly used Gaussian pulses. Single-band pulse and dual-band pulse were combined to excite the resonances of given metabolites. An optimized MEGA-PRESS sequence was implemented on the uMR780 magnetic resonance imaging system manufactured by United Imaging Healthcare (UIH). The results showed that the SLR pulse could reduce the interference of macromolecule (MM) on GABA signal. Compared with the traditional methods, combining the single-band and dual-band pulses could better suppress contamination of residual water signal to the GABA* signal. Volunteer experiments demonstrated that the optimized MEGA-PRESS sequence improved in vivo measurement of GABA*concentration.关键词
磁共振波谱(MRS)/序列优化/MEGA-PRESS/γ-氨基丁酸(GABA)Key words
magnetic resonance spectroscopy (MRS)/sequence optimization/MEGA-PRESS/γ-aminobutyric acid (GABA)分类
数理科学引用本文复制引用
花蕊,孙钰,温林飞,刘慧,万遂人..在体检测γ-氨基丁酸的MEGA-PRESS序列优化设计[J].波谱学杂志,2018,35(2):188-197,10.基金项目
国家自然基金国家重大科研仪器设备研制专项(21327902). （21327902）
