波谱学杂志2018，Vol.35Issue(2)：204-214,11.DOI:10.11938/cjmr20172602
一种1,4-噻嗪酰胺类FKBPs配体的波谱学数据解析
Spectral Analysis of a 1,4-Thiazinamide FKBPs Ligand
摘要
Abstract
(3R)-4-[(4-methylphenylsulfonyl)]-1,4-thiazine-3-acyl-[(2R)-2-amino-4-methyl]-pentanoic acid isopropyl ester (ID: HD5-6) is a ligand of FK506 binding proteins (FKBPs), which we developed and had proprietary intellectual property rights for. The compound facilitates nerve regeneration, and can potentially developed in drugs for treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis and stroke. In this study, one-dimensional (1D) and two-dimensional nuclear magnetic resonance (NMR) spectroscopy (including 1H NMR, 13C NMR, DEPT, 1D NOESY, 1H-1H COSY, 1H-13C HSQC and 1H-13C HMBC), combined with mass spectrometry (MS), ultraviolet spectroscopy (UV) and infrared spectroscopy (IR), were used to elucidate the structure of the compound. All 1H and 13C NMR signals were assigned.关键词
核磁共振(NMR)/结构确证/噻嗪酰胺类衍生物/FKBPs配体/红外光谱(IR)/质谱(MS)/紫外光谱(UV)Key words
nuclear magnetic resonance (NMR)/structural elucidation/thiazine amide derivatives/FKBPs ligands/infrared spectroscopy (IR)/mass spectrometry (MS)/ultraviolet spectroscopy (UV)分类
数理科学引用本文复制引用
姜丹,王巍,毕倩楠,苏丹丹..一种1,4-噻嗪酰胺类FKBPs配体的波谱学数据解析[J].波谱学杂志,2018,35(2):204-214,11.基金项目
国家重大新药创制专项课题资助项目(2009ZX09103-024) （2009ZX09103-024）
国家高新技术研究计划("863"计划)资助项目(2012AA020301). （"863"计划）
