波谱学杂志2018，Vol.35Issue(2)：255-267,13.DOI:10.11938/cjmr20172599
质子化学位移各向异性的测量
Measurements of Proton Chemical Shift Anisotropy
摘要
Abstract
1H chemical shift anisotropy (CSA) measurements are useful for understanding molecule structure and dynamics. However, technically it remains a challenge due to strong 1H-1H homonuclear dipolar coupling interaction and relatively small 1H chemical shift anisotropy, especially in proteins with multiple proton sites. Here the current methods for 1H chemical shift anisotropy measurement are reviewed, including homonuclear decoupling slow magic angle spinning, ultrafast magic angle spinning, symmetry-based recoupling (RNnv) method, xCSA and quantum chemical calculations. Measurements of protein amide proton chemical shift anisotropy using solid state nuclear magnetic resonance (NMR) under fast magic angle spinning and correlations of amide proton chemical shift anisotropy with protein secondary structure/hydrogen bond length are discussed.关键词
固体核磁共振/综述/化学位移各向异性(CSA)/质子/氢键Key words
solid-state NMR/review/chemical shift anisotropy(CSA)/proton/hydrogen bond分类
数理科学引用本文复制引用
葛玉玮,刘买利,甘哲宏,李从刚..质子化学位移各向异性的测量[J].波谱学杂志,2018,35(2):255-267,13.基金项目
国家自然科学基金资助项目(21575156) （21575156）
国家重点基础研究发展计划("973"计划)资助项目(2017YFA0505400). （"973"计划）
