重庆医学2018，Vol.47Issue(14)：1889-1895,7.DOI:10.3969/j.issn.1671-8348.2018.14.013
多个单核苷酸多态性位点与食管癌和胃癌患病风险的相关性分析
Analysis on correlation between multiple single nucleotide polymorphisms loci and risk of esophageal and gastric cancer
摘要
Abstract
Objective To investigate the association between multiple single nucleotide polymorphisms (SNP) with esophageal and gastric cancer,and to search the shared genetic risk loci for esophageal and gastric cancer in Han population of Henan Province.Methods Five hundreds cases of esophageal cancer,600 cases of gastric cancer and 600 persons undergoing physical examination in the Henan Provincial Tumor Hospital were selected.Seven SNP loci were selected.The genotyping was performed by adopting the Sequenom MassAR-RAY SNP genoting technique.The relative odds ratios(OR) and 95 ％ confidence intervals(CI) were calculated by unconditional logistic regression.Results In allelic model,the two SNP loci were correlated with the risk of esophageal cancer,which were rs4785204 (OR =1.43,95 ％ CI:1.12-1.85,P =0.01) and rs4924935 (OR =0.76,95 ％CI:0.61-0.99,P=0.04).The four SNP loci were correlated with the risk of gastric cancer,gastric cancer,which were rs13361707(OR=1.23,95％CI:1.13-1.56,P=0.00),rs4779584(OR=1.25,95％CI:1.11-1.58,P=0.04),rs4785204(OR=1.24,95％CI:1.03-1.49,P=0.03)and rs4924935(OR=0.76,95％ CI:0.60-0.99,P =0.04).In the genetic model analysis,the four loci were significantly correlated with the risk of esophageal cancer,which were rs6687758,rs401681,rs4785204 and rs4924935(P＜0.05);the three loci were correlated with the gastric cancer,which were rs13361707,rs4779584 and rs4785204(P＜0.05).Conclusion Multiple SNP loci have the relationship with the risk of esophageal and gastric cancer in Han population of Henan Province.The genetic variation of rs4785204 and rs4924935 loci may simultaneously play an important role in the occurrence and development of esophageal and gastric cancer.关键词
食管肿瘤/胃肿瘤/多态性；单核苷酸/疾病遗传易感性Key words
esophageal neoplasms/stomach neoplasms/polymorphism, single nucleotide/genetic predisposition to disease分类
医药卫生引用本文复制引用
黄建新,李馨,王瑜,鲁朝敏..多个单核苷酸多态性位点与食管癌和胃癌患病风险的相关性分析[J].重庆医学,2018,47(14):1889-1895,7.基金项目
河南省科技计划资助项目(51010205). （51010205）
