动物医学进展2018，Vol.39Issue(4)：59-62,4.
高温对大鼠组织CS、OGDH含量和下丘脑线粒体数量的影响
Effects of High Temperature on CS,OGDH Contents and Hypothalamus Mitochondria Numbers in Rats
摘要
Abstract
In this study,we observed the effects of high temperature environment on gastrocnemius and liver citrate synthase (CS),ketoglutarate dehydrogenase (OGDH)contents,hypothalamus mitochondria num-bers and other energy metabolism-related indexes in normal and central anesthetized rats.40 SPF grade SD rats were randomly divided into normal temperature control group (normal group),high temperature nor-mal control group (high group),normal temperature central anesthesia group(normal anesthesia group), high temperature central anesthesia group(high anesthesia group).Glucose(GLU),total cholesterol (TC), triglyceride (TG)and gastrocnemius and liver CS,OGDH were measured after 30 days continuous feeding. The numbers of mitochondria in hypothalamus were also observed.The result showed that both the body weight and liver OGDH in the high group and high anesthesia group,the serum TC in the normal anesthe-sia group and high anesthesia group,the liver CS in the high group and normal anesthesia group were sig-nificantly lower than those in the normal group(P<0.01,P<0.05).Both the serum TG and gastrocnemius OGDH in the high group and high anesthesia group,and the gastrocnemius CS and hypothalamus mito-chondria numbers in the normal anesthesia group and high anesthesia group were significantly higher than those in the normal group(P<0.01,P<0.05).Both the bodyweight and liver OGDH in the high group and high anesthesia group,and the gastrocnemius CS and hypothalamus mitochondria numbers in the high group were significantly lower than those in the normal anesthesia group(P<0.01,P<0.05);The serum TG in the high group and high anesthesia group as well as the liver CS in the high anesthesia group were significantly higher than those in the normal anesthesia group(P<0.01,P<0.05).As for the conclusion, high temperature can reduce the body weight,serum TC,liver OGDH,and increase serum TG,gastrocne-mius OGDH and gastrocnemius CS in rats.Central nervous anesthesia has a certain synergistic effect,and can significantly increase the numbers of hypothalamus mitochondria in rats.High temperature has syner-gistic effect.关键词
SD大鼠/高温/柠檬酸合酶/酮戊二酸脱氢酶/线粒体Key words
SD rat/high temperature/citrate synthase/oxoglutarate dehydrogenase/mitochondria分类
农业科技引用本文复制引用
姚凤云,张大玲,王炳志,刘春花,翁美芝,左铮云..高温对大鼠组织CS、OGDH含量和下丘脑线粒体数量的影响[J].动物医学进展,2018,39(4):59-62,4.基金项目
国家自然科学基金项目(81503489,81260524) （81503489,81260524）
江西省普通本科高校中青年教师发展计划访问学者专项资金资助项目(赣教办函﹝2016﹞169号) （赣教办函﹝2016﹞169号）
