动物营养学报2018，Vol.30Issue(5)：1845-1853,9.DOI:10.3969/j.issn.1006-267x.2018.05.027
血根碱对断奶仔猪生长性能、肠道形态结构及小肠黏膜免疫功能的影响
Effects of Dietary Sanguinarine on Growth Performance, Intestinal Mucosal Morphology and Immune Function of Small Intestinal Mucosa of Weaned Piglets
摘要
Abstract
This experiment was conducted to study the effects of dietary sanguinarine(SAN)on growth per-formance, intestinal mucosal morphology and immune function of small intestinal mucosa of weaned piglets. Thirty-six"Duroc×Landrace×Yorkshire"hybrid pigs with initial weight of(6.55±0.18)kg were randomly di-vided into three groups with twelve replicates per group and one pig per replicate according to similar body weight and the same ratio of gender. The pigs in the control group were fed a basal diet, those in antibiotic group were fed the basal diet supplemented with 75 mg/kg chlortetracycline,and the others in SAN group were fed the basal diet supplemented with 50 mg/kg sanguinarine. The experiment lasted for 21 days. The results showed as follows:1)compared with the control group, the average daily gain and the average daily feed in-take were significantly increased(P<0.05), and the ratio of feed to gain and diarrhea rate were significantly decreased(P<0.05)in SAN group and antibiotic group. But there were no significant differences in above growth performance indices between SAN group and antibiotic group(P>0.05).2)Compared with the control group, the villus height and the ratio of villus height to crypt depth(V/C)of duodenum and jejunum were sig-nificantly increased(P<0.05 or P<0.01)in SAN group and antibiotic group, and no significant differences were found in above indices between SAN group and antibiotic group(P>0.05), while the villus height and V/C of ileum in SAN group were significantly higher than those in the other two groups(P<0.05). 3)Com-pared with the control group,the contents of immunoglobulin A(IgA),immunoglobulin G(IgG)and immu-noglobulin M(IgM)in duodenum, jejunum and ileum in SAN group and antibiotic group were significantly increased(P<0.05 or P<0.01)except the IgG content in duodenum mucosa and the IgM content in jejunum mucosa. But no significant differences were found in above indices between SAN group and antibiotic group (P>0.05). In conclusion,dietary sanguinarine with the same effects of antibiotic can improve intestinal muco-sal morphology,and increase small intestinal mucosal immune function,consequently improve the growth per-formance of weaned piglets.关键词
血根碱/断奶仔猪/生长性能/肠道形态结构/免疫球蛋白Key words
sanguinarine/weaned piglets/growth performance/intestinal mucosal morphology/immunoglob-ulin分类
农业科技引用本文复制引用
陈家顺,康宝聚,曾建国,胡海波,赵玉蓉,陈柳,姚康,符晨星..血根碱对断奶仔猪生长性能、肠道形态结构及小肠黏膜免疫功能的影响[J].动物营养学报,2018,30(5):1845-1853,9.基金项目
国家自然科学基金青年科学基金项目(31702126) （31702126）
湖南省研究生科研创新项目(CX2017B348) （CX2017B348）
湖南省教育厅科学研究项目优秀青年项目(17B121) （17B121）
湖南省"湖湘青年科技创新人才"项目(2015RS4053) （2015RS4053）
中科院"百人计划"项目 （）
