国际妇产科学杂志2018，Vol.45Issue(2)：188-191,4.
棕色脂肪组织及其与多囊卵巢综合征相关性研究新进展
New Research Progress on the Relationship between Brown Fat Tissue and Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovarian syndrome (PCOS) is a common disorder of reproductive metabolism with high heterogeneity.Its main manifestations are obesity,insulin resistance (IR),hirsutism,infertility,late onset of cardiovascular and cerebrovascular diseases,ovarian cancer and other long-term complications.Brown adipose tissue (BAT) is the main body heat producing tissue and plays an important role in metabolism.It has been found that BAT is closely related to the formation of PCOS.On the one hand,obesity caused by metabolic disorders of BAT further accelerates the occurrence of abnormal ovulation and related complications;on the other hand,the cytokines secreted by BAT are the key to alleviate IR and reduce the inflammatory state of PCOS.Based on the study of the relationship between BAT and PCOS,we have derived the treatment methods including exogenous BAT transplantation,iris factor supplement,drug-induced adipose tissue browning and so on,so as to diversify the treatment methods of PCOS.In this paper,the research progress of BAT and its relationship with PCOS is reviewed.关键词
脂肪组织,棕色/多囊卵巢综合征/胰岛素抗药性/肥胖症/代谢综合征Key words
Adipose tissue, brown/Polycystic ovary syndrome/Insulin resistance/Obesity/Metabolic syndrome引用本文复制引用
李子涵,张宁,武志娟,周冠伦,李晓霞..棕色脂肪组织及其与多囊卵巢综合征相关性研究新进展[J].国际妇产科学杂志,2018,45(2):188-191,4.基金项目
山东省自然科学基金(ZR2017BH062) （ZR2017BH062）
山东省重点研发计划项目(2017GSF19107) （2017GSF19107）
