广西医科大学学报2018，Vol.35Issue(5)：683-686,4.DOI:10.16190/j.cnki.45-1211/r.2018.05.024
哮喘患儿血清干扰素γ诱导蛋白10水平及其临床意义
The serum level of interferon-γ inducible protein 10 in children with asthma and its clinical significance
摘要
Abstract
Objective:To investigate the serum level of interferon-γ inducible protein 10(IP-10) in children with asthma and its clinical significance.Methods:72 children with asthma and 25 healthy children were enrolled in this study.The IP-10 level in serum was detected.The correlation between IP-10 level and asthma severity was analyzed.The value of IP-10 for predicting viral-induced asthma was analyzed by receiver operating characteristic(ROC) curve.Results:Viral-induced asthma children accounted for more than 60％ of 72 children with asthma,and had significantly higher level of IP-10 and more severe asthma attacks than those with non-viral asthma and healthy controls(P＜0.05).There was a positive correlation between the serum IP-10 level and asthma severity(r =0.763,P =0.002).The area under the ROC curve of IP-10 for the diagnosis of viral-induced asthma was 0.852 with cut-off value of 48.45 ng/L.Conclusion:Serum IP-10 level could be an effective predictive marker of viral-induced asthma in children.关键词
小儿哮喘/IP-10/病毒诱导性哮喘Key words
pediatric asthma/IP-10/viral-induced asthma分类
医药卫生引用本文复制引用
王长英,阳明玉..哮喘患儿血清干扰素γ诱导蛋白10水平及其临床意义[J].广西医科大学学报,2018,35(5):683-686,4.基金项目
广西壮族自治区教育厅科研基金资助项目(No.LX2014261) （No.LX2014261）
