河北医学2018，Vol.24Issue(5)：730-734,5.DOI:10.3969/j.issn.1006-6233.2018.05.007
脐带血血清总胆红素检测在新生儿ABO溶血病早期诊治中的临床价值
The Clinical Application Value of Umbilical Cord Blood Serum Total Bilirubin Detection in the Early Diagnosis and treatment of ABO Hemolytic Disease of the Newborn
摘要
Abstract
Objective:To explore the clinical value of cord blood serum total bilirubin in the early diag-nosis and treatment of neonatal ABO hemolytic disease,and to provide experience and reference for clinical di-agnosis and treatment. Methods: From October 2015 to October 2017, 320 neonates with ABO blood group mismatch in our hospital were selected as the study samples to detect three indexes of neonatal ABO hemolysis. The serum total bilirubin level of umbilical cord blood was measured by automatic biochemical analyzer, and the relationship between serum total bilirubin and maternal and infant blood group, time of jaundice and he-molysis was analyzed. Results:There was no significant difference between maternal and infant O - A blood type and mother -to -infant O -B blood type in the incidence of ABO hemolytic disease,incidence of high bilirubin,total bilirubin in cord blood serum,anti -human globulin test and release test. In the age of less than or equal to 3 days of neonatal umbilical cord blood serum total bilirubin was significantly higher than that of age greater than 3 days in neonatal hyperbilirubinemia, the difference was statistically significant (P<0. 05). Coombs test positive children's umbilical cord blood total bilirubin was significantly higher than that of antiglobulin test negative patients, the difference was statistically significant (P<0.05). Conclusion: The three detection of serum total bilirubin and hemolysis of umbilical cord blood in neonates with ABO incompati-ble blood group is of great significance in the early diagnosis and treatment of ABO hemolytic disease of the newborn.关键词
脐带血/总胆红素/新生儿ABO溶血病Key words
Umbilical cord blood/Total bilirubin/Neonatal ABO hemolytic disease引用本文复制引用
姚超峰..脐带血血清总胆红素检测在新生儿ABO溶血病早期诊治中的临床价值[J].河北医学,2018,24(5):730-734,5.基金项目
陕西省科技计划项目,(编号:2012K15-02-10) （编号:2012K15-02-10）
