河北医学2018，Vol.24Issue(5)：820-823,4.DOI:10.3969/j.issn.1006-6233.2018.05.031
纤溶酶与阿托伐他汀联合治疗短暂性脑缺血发作的临床研究
Clinical Study of Fibrinolytic Enzyme combined with Atorvastatin in the Treatment of Transient Ischemic Attack
摘要
Abstract
Objective:To investigate the clinical efficacy of plasmin (Plm) combined with atorvastatin (ATV) on transient ischemic attack (TIA) and its impact on the hemorheology and serum matrix metallopro-teinase - 9 (MMP-9),hypersensitivity C-reactive protein(hs-CRP) levels in patients. Methods:100 ca-ses of TIA in our hospital from February 2015 to February 2017 were selected and divided into two groups by random number table. The control group(50 cases) was treated with ATV,and the observation group(50 ca-ses) was additionally treated with Plm. The clinical efficacy,the changes of Hemorheology and serum MMP-9 and hs-CRP levels and the incidence of adverse reactions before and after treatment were recorded and com-pared between the two groups. Results:After 4 weeks of treatment, the total effective rate of the observation group was 94%,which was significantly higher than that of the control group(74%,P<0.05).Compared with before treatment,the values of high shear viscosity (HBV),whole blood low shear viscosity (LBV),plasma viscosity (SV) and red cell backlog (HCT) were significantly decreased in the two groups after 4 weeks of treatment (P<0.01),and the blood rheology indexes above the observation group were significantly lower than those of the control group(P<0.01). After two weeks of treatment,the serum levels of MMP-9 and hs-CRP were significantly decreased (P<0.01) in the 4 groups, and the decrease in the observation group was more significant (P<0.01). Compared with the control group (10%), the adverse reaction rate in the observation group was 6%,the difference was not statistically significant (P>0.05). Conclusion:The combination of fi-brinolytic enzyme and atorvastatin in the treatment of transient ischemic attack can effectively relieve the symp-toms and signs of the patients,improve the blood rheology and microcirculation of the body significantly,and the curative effect is better and safe and reliable.关键词
短暂性脑缺血发作/纤溶酶/阿托伐他汀/血液流变学Key words
Transient ischemic attack/Plasmin/Atorvastatin/Hemorheology引用本文复制引用
李鱼,江宗泽..纤溶酶与阿托伐他汀联合治疗短暂性脑缺血发作的临床研究[J].河北医学,2018,24(5):820-823,4.基金项目
重庆市科技计划项目,(编号:2010J056) （编号:2010J056）
