郑州大学学报（医学版）2018，Vol.53Issue(3)：289-293,5.DOI:10.13705/j.issn.1671-6825.2017.10.004
恒河猴卵巢组织中年龄相关性差异基因的生物信息学分析
Bioinformation analysis of age-related differentially expressed genes in Macaca mulatta ovary tissues
摘要
Abstract
Aim:To explore the potential of biomarkers and signaling pathways affected by aging in Macaca mulatta o-vary tissue.Methods:The gene chip GSE44533 was downloaded from GSE database. There contained 9 ovarian Macaca mulatta samples,and they were allocated into three groups according to the age, 3 samples in each group. Young group were 3 to 4 years old,middle group were 7 to 8 years old and old group were 18 to 19 years old. After the differentially ex-pressed genes(DEGs) of three groups were screened,GO analysis and KEGG signaling pathways analysis were conducted, and the protein-protein interaction network(PPI) was constructed. Results and Conclusion: There were 253 DEGs be-tween young and middle group,68 DEGs between middle and old group,and 636 DEGs between young and old group. Ac-cording to the GO and KEGG analysis,these DEGs were partly related to oocyte meiosis,pyruvate metabolic pathway and so on. Six DEGs(SNRNP200, DDX46, SNRNP35, DAZ2, ELAVL2, RBM46) between young and old group appeared cell-molecule interactions,which can be used as a new direction.关键词
卵巢/老龄化/差异表达基因/恒河猴/生物信息学Key words
ovary/aging/differentially expressed gene/Macaca mulatta/bioinformatics分类
医药卫生引用本文复制引用
冀萌萌,余增丽,谭雪梅,余凯伦,张秀丽,王宗立,陶宇昌,刘蔓蔓,高湛,刘小转..恒河猴卵巢组织中年龄相关性差异基因的生物信息学分析[J].郑州大学学报（医学版）,2018,53(3):289-293,5.基金项目
国家自然科学基金资助项目(30500540) （30500540）
