郑州大学学报（医学版）2018，Vol.53Issue(3)：381-385,5.DOI:10.13705/j.issn.1671-6825.2017.11.053
孕期针对性补充叶酸对血清HCY水平的影响
Effect of targeted supplementation of folic acid during pregnancy on ser-um homocysteine levels of women
摘要
Abstract
Aim:To investigate the effects of different doses of folic acid supplementation on the serum homocysteine levels of pregnant women with different genetic characteristics.Methods: A total of 1 432 pregnant women who received regular perinatal care were selected. Oral mucosal epithelial cells were collected from these women. The Taqman-MGB probe was used to examine the C677T and A1298C loci in the 5,10-methylenetetrahydrofolate reductase(MTHFR) gene and the A66G locus in the methionine synthase reductase(MTRR) gene. Based on their folic acid utilization ability,the in-cluded women were allocated into no-risk,low-risk,moderate-risk,and high-risk groups. Based on the dosage of folic acid supplementation,the no-risk group was further divided into non-intervention group and 0.4 folic acid mg group, and the low-risk,moderate-risk,and high-risk groups were further divided into 0.4 mg and 0.8 mg folic acid groups. The level of homocysteine in the peripheral blood of the study subjects during early,mid-,and late pregnancy was examined. Results:In no-risk group,the pregnant women with 0.4 mg folic acid supplementation had lower serum level of homocysteine during early,mid-,and late pregnancy than those not intervented(P<0.05); in low-risk group, there was no significant differ-ence in serum homocysteine level between the pregnant women with 0.4 mg folic acid supplementation and 0.8 mg folic acid supplementation during early,mid-,and late pregnancy(P>0.05);in moderate-risk group and high-risk group,dur-ing early,mid-,and late pregnancy,the serum homocysteine level in the pregnant women with 0.4 mg folic acid supple-mentation was significantly higher compared with those with 0.8 mg folic acid supplementation(P<0.05). The serum ho-mocysteine level of the pregnant women with 0.4 mg folic acid supplementation in no-risk group and low-risk group as well as those with 0.8 mg folic acid supplementation in moderate-risk group and high-risk group showed a downward trend during pregnancy. Conclusion:Individuals with distinct genetic characteristics have different demands for folic acid,so the per-sonalized supplementation of folic acid could keep a stable level of serum homocysteine in pregnancy,which could prevent the increase of late pregnancy homocysteine concentration,and improve pregnancy outcome.关键词
妊娠妇女/叶酸利用能力/血清HCYKey words
pregnant women/folic acid utilization ability/serum homocysteine分类
医药卫生引用本文复制引用
许雅娟,罗晓华,刘月华,韩宁,洪腾,翟闪闪,柳蕊,任利单,余艳茹,班彦杰,冉利敏,胡璐璐..孕期针对性补充叶酸对血清HCY水平的影响[J].郑州大学学报（医学版）,2018,53(3):381-385,5.基金项目
河南省医学科技攻关计划基金资助项目(201403110) （201403110）
