临床肝胆病杂志2018，Vol.34Issue(5)：1001-1004,4.DOI:10.3969/j.issn.1001-5256.2018.05.015
聚乙二醇干扰素α-2a治疗非活动性HBsAg携带者HBsAg清除与血清粒-巨噬细胞集落刺激因子水平的关系
Association between HBsAg clearance and serum level of granulocyte-macrophage colony stimulating factor in inactive HBsAg carriers receiving pegylated interferon alpha-2a
摘要
Abstract
Objective To investigate the association between HBsAg clearance and serum level of granulocyte-macrophage colony stimulating factor (GM-CSF) in inactive HBsAg carriers receiving pegylated interferon (PEG-IFN) alpha-2a.Methods A total of 20 inactive HBsAg carriers who visited Beijing YouAn Hospital,Capital Medical University,from January 2013 to January 2016 were enrolled,and after 24 weeks of PEG-IFN alpha-2a treatment,13 achieved HBsAg clearance (R group) and 7 did not achieve HBsAg clearance (NR group).The Lurninex technique was used to measure the serum level of GM-CSF at baseline and at weeks 12 and 24 of treatment.The serum level of GM-CSF was also measured for 11 healthy controls (HC group).The t-test or an analysis of variance was used for comparison of continuous data between groups,and the Bonferroni test was used for further comparison between two groups.The chi-square test was used for comparison of categorical data between groups.Results The R and NR groups had a significantly higher serum GM-CSF level than the HC group (42.63 ±11.24 pg/ml and 46.77 ± 10.52 pg/ml vs 11.97 ± 3.85 pg/ml),and there was a significant difference between the three groups (F =4.482,P =0.02).At weeks 12 and 24 of PEG-IFNα-2a treatment,the R group had a significantly higher serum GM-CSF level than the NR group (t =22.422 and 17.782,both P ＜0.05).In the R group,the serum GM-CSF level was 42.63 ± 11.25 pg/ml at baseline,significantly increased to 83.31 ± 14.20 pg/ral at week 12 of treatment,and then significantly decreased to 32.34 ±8.06 pg/ml at week 24 of treatment (F=7.655,P =0.002).In the NR group,the serum GM-CSF level was 46.77 ± 10.52 pg/ml at baseline and significantly decreased to 25.90 ± 7.06 pg/ml at week 12 of treatment and 9.43 ± 2.45 pg/ml at week 24 of treatment (F =5.264,P =0.016).Conclusion In inactive HBsAg carriers receiving PEG-IFN alpha-2a treatment,the increase in serum GM-CSF level may indicate HBsAg clearance.关键词
肝炎病毒,乙型/肝炎表面抗原,乙型/聚乙烯二醇类/干扰素类/粒细胞巨噬细胞集落刺激因子Key words
hepatitis B virus/hepatitis b surface antigens/polyethylene glycols/interferons/granulocyte-macrophage colony-stimulating factor分类
医药卫生引用本文复制引用
曹振环,鲁俊锋,武亚丽,郑燕红,陈新月..聚乙二醇干扰素α-2a治疗非活动性HBsAg携带者HBsAg清除与血清粒-巨噬细胞集落刺激因子水平的关系[J].临床肝胆病杂志,2018,34(5):1001-1004,4.基金项目
“十三五”国家重大科技专项(2017ZX10202201) （2017ZX10202201）
首都临床特色应用研究(Z161100000516018) （Z161100000516018）
首都临床特色应用研究(Z171100001017062) （Z171100001017062）
首都卫生发展科研重点专项项目(首发2016-1-2183) （首发2016-1-2183）
北京市自然科学基金(7182073) （7182073）
首都卫生发展科研专项(首发2018-2-2183) （首发2018-2-2183）
北京市医院管理局青年人才培养“青苗”计划(QML20161701) （QML20161701）
北京市教委科技发展基金(11720674) （11720674）
