临床肝胆病杂志2018，Vol.34Issue(5)：1115-1118,4.DOI:10.3969/j.issn.1001-5256.2018.05.041
鹅脱氧胆酸及其衍生物在肝胆肿瘤中的作用机制
The mechanism of chenodeoxycholic acid and its derivatives in hepatobiliary tumor
摘要
Abstract
Chenodeoxycholic acid (CDCA) is a primary bile acid and is involved in the digestion,transportation,and absorption of nutriments in the hepatobiliary system.Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily.In vivo and in vitro studies have demonstrated that CDCA is the natural ligand for FXR and involved in many cell signaling pathways,and it can inhibit the proliferation and induce the apoptosis of hepatobiliary tumor cells.This article reviews the association between CDCA and hepatobiliary tumor.关键词
肝肿瘤/胆道肿瘤/鹅脱氧胆酸/综述Key words
liver neoplasms/biliary tract neoplasms/chenodeoxycholic acid/review分类
医药卫生引用本文复制引用
祁飞,唐映梅..鹅脱氧胆酸及其衍生物在肝胆肿瘤中的作用机制[J].临床肝胆病杂志,2018,34(5):1115-1118,4.基金项目
云南省卫生科技计划项目(2014N5109、2017NS280) （2014N5109、2017NS280）
昆明医科大学研究生创新基金(2017S103) （2017S103）
