老年医学与保健2018，Vol.24Issue(2)：118-120,3.
阿哌沙班在非瓣膜性心房颤动患者抗凝治疗的前瞻性研究
Prospective Study on Apixaban in Anticoagulant Treatment of Nonvalvular Atrial Fibrillation
陈蕙萍 1叶永刚2
作者信息
- 1. 上海交通大学医学院附属同仁医院(上海市同仁医院)内科,上海200336
- 2. 上海交通大学医学院附属同仁医院(上海市同仁医院)心内科,上海200336
- 折叠
摘要
Abstract
Objective To observe the efficiency and safety of apixaban in the prevention of ischemic stroke in patients with nonvalvular atrial fibrillation (AF) patients.Methods 45 cases with nonvalvular atrial fibrillation from inpatients and out patients were selected to be treatment group and apixaban was administrated (5 mg,twice a day) while 54 cases from inpatients treated with warfarin were selected to be control group;follow-up was performed 3 months after drug administration;a comparative study was made to the occurrence in ischemic stroke,non-central nerve system thrombosis,hemorrhage and other side effects between the 2 groups.Results The total occurrence of thrombosis and that of hemorrhage in treatment group were both lower than those in control group with statistical differences (x2=5.0366,P=0.0248;x2-=4.6200,P=0.0316) while existed no difference of statistical significance in side effects between the 2 groups (P＞0.05).Conclusions Apixaban is of better effect with superior safety on AF patients in preventing ischemic stroke than warfarin;it is worthy of wider clinical application.关键词
抗凝药/心房颤动/阿哌沙班/卒中Key words
anticoagulants/atiral fibrillation/apixaban/stroke引用本文复制引用
陈蕙萍,叶永刚..阿哌沙班在非瓣膜性心房颤动患者抗凝治疗的前瞻性研究[J].老年医学与保健,2018,24(2):118-120,3.
