老年医学与保健2018，Vol.24Issue(2)：123-126,4.
老年2型糖尿病患者血糖波动与颈动脉内膜中层厚度的关系
Correlation between Blood Glucose Excursion and Carotid Intima-media Thickness in the Elderly with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To explore the correlation between blood glucose excursion and carotid intima-media thickness (CIMT) in the elderly with type 2 diabetes mellitus.Methods 59 elderly hospitalized during the period from Jan.,2014 to Dec.,2015 were selected;continuous glucose monitoring system (CGMS) was applied in monitoring 72 h blood glucose of all the cases and Doppler ultrasound examination in measuring CIMT;the levels of glycosylated hemoglobin (HbAlc),C-peptide,triglyceride,total cholesterol,high-density lipoprotein and low density lipoprotein were detected;the 59 cases were divided,based on the median of mean amplitude of blood glucose excursion,into 2 groups:group A (with greater excursions) and group B (with smaller excursions).Results There existed no statistical difference in the clinical data (including sex,age,C-reactive protein,total cholesterol,low density cholesterol,triglyceride,alanine transaminase,serum creatinine,fasting blood glucose,2 hours postprandial blood glucose (P2hBG) and average blood glucose) between the 2 group (P＞ 0.05);the level of A1 (HbA1c) of the cases in group A increased much more than that of the cases in group B [(8.74±2.41) ％ vs (7.39± 1.58) ％,P=0.015] while beta-cell function was lower in Group A than in Group B [fasting C-peptide;0.7 (0.3-1.4)vs 1.6 (0.78-2.13) ng/mL,P=0.004;2 h C-peptide:1.8 (1.1-2.9) vs 3.45 (1.35-5.13) ng/mL,P--0.018];the absolute difference of day-to-day blood glucose excursions and mean amplitude of glucose excursions were greater in Group A than those in Group B [(2.11±1.12) vs (1.23±0.56) mmol/L,P=0.001;(5.90±1.48) vs (2.54±0.92) mmol/L,P＜0.001];regression analysis indicated that mean amplitude of glucose excursions was the independent risk factor of increased CIMT while 2 h C-peptide was the protective factor of increased CIMT.Conclusions Blood glucose excursion is correlated to CIMT in the elderly with type 2 diabetes mellitus,which may be the risk factor of cardio-cerebrovascular diseases in the elderly with diabetes mellitus.关键词
老年/2型糖尿病/血糖波动/颈动脉内膜中层厚度Key words
elderly/type 2 diabetes mellitus/blood glucose excursions/carotid intima-media thickness (CIMT)引用本文复制引用
冯强,蒋翠萍,孙华,徐媛媛,谭雯,陶晓明,顾芹,孙皎..老年2型糖尿病患者血糖波动与颈动脉内膜中层厚度的关系[J].老年医学与保健,2018,24(2):123-126,4.基金项目
上海市卫生和计划生育委员会课题(20134448) （20134448）
