老年医学与保健2018，Vol.24Issue(2)：154-156,160,4.
同源盒基因A10表达下调后抑制胃癌细胞裸鼠皮下成瘤能力及相关机制研究
HOXA10 with Down-regulated Expression in Inhibiting Xenograft Tumor Formation of Gastric Cancer Cell and the Mechanism
宋晨龙 1周崇治1
作者信息
- 1. 上海交通大学附属第一人民医院普外科,上海200080
- 折叠
摘要
Abstract
Objective To investigate the effect of homeobox gene A10 (HOXA10) with changed expression level on xenograft tumor formation of gastric cancer cell and the possible mechanism.Methods Bioinformatics analysis was made to the expression of HOXA10 in gastric cancer in The Cancer Genome Atlas website (TCGA) database;stable HOXA10 knockdown gastric cancer cell line BGC-823-sh-HOXA10 was constructed and performed in the xenograft tumor formation assay;the expression of apoptosis related protein Bcl-xL was detected by western blot.Results The analysis of TCGA database showed that the expression of HOXA 10 in gastric cancer was up-regulated;HOXA10 knockdown impaired the ability of xenograft tumor formation in BGC-823 cell line and the expression of Bcl-xL was down-regulated.Conclusions HOXA10 was upregulated in gastric cancer;HOXA10 knockdown may inhibit the ability of xenograft tumor formation in BGC-823 cell line and the down-regulation of antiapoptosis protein Bcl-xL after HOXA10 knockdown may be the possible mechanism.关键词
胃肿瘤/同源盒基因A10/裸鼠皮下成瘤/B细胞淋巴瘤/白血病-xLKey words
stomach neoplasms/homeobox gene A10 (HOXA10)/xenograft tumor formation/Bcl-xL引用本文复制引用
宋晨龙,周崇治..同源盒基因A10表达下调后抑制胃癌细胞裸鼠皮下成瘤能力及相关机制研究[J].老年医学与保健,2018,24(2):154-156,160,4.
