摘要
Abstract
Objective To explore the correlation between red blood cell distribution width (RDW) and glomerular filtration rate (GFR) in the elderly with diabetic nephropathy.Methods 264 elderly patients with type 2 diabetes were divided into 3 groups:simple diabetes mellitus group (MD group) (n=164),early diabetic nephropathy (EDN group) (n=60) and clinical diabetic nephropathy group (CDN group) (n=40),and 60 norm were selected to be control group;detections were made to serum creatinine (Cr),fasting blood glucose (FBG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),triglyceride (TG),uric acid (UA),alanine aminotransferase (ALT),sensitive-C-reactive protein (Hs-CRP),glycatedhemoglobin (HbA1c),RDW,serum ferritin (SF),ratio of albumin/creatinine (ACR) and eGRF and statistical analysis was made to the changes of RDW in each group and to the correlation among the related index.Results The levels of RDW in each of the diabetes groups were higher than that in control group [(38.8±5.8) fl vs (35.1±5.4) fl,P＜0.05],and the level of RDW kept increasing with the decreasing of eGFR (P＜0.05);in EDN group,the level of RDW was in negative correlation with the levels of HbAlc and eGFR (P＜0.05)while in positive correlation with diabetes duration and the levels of HbA1c,FBG,TC,TG,HDL-C,UA,Cr,ACR and Hs-CRP (P＜0.05);multiple stepwise regression analysis indicated that diabetes duration,HbA1c,RDW and ACR were the independent risk factors of eGFR (P＜0.05).Conclusions eGFR decreases when RDW increases,there exists certain correlation between them;RDW may be taken as an early diagnosing biomarker of diabetic nephropathy.关键词
红细胞分布宽度/糖尿病肾病/尿白蛋白/肌酐/肾小球滤过率Key words
red blood cell distribution width (RDW)/diabetic nephropathy/ratio of albumin/creatinine (ACR)/glomerular filtration rate (GFR)
