山东医药2017，Vol.57Issue(47)：13-16,4.DOI:10.3969/j.issn.1002-266X.2017.47.004
MSA、CEA、NLR联合检测对小细胞肺癌的诊断及鉴别诊断效能
Application value of detection of peripheral MSA, CEA, and NLR in diagnosis and differential diagnosis of small cell lung cancer
摘要
Abstract
Objective To observe the application value of detection of serum anti-spindle antibodies (MSA),carcinoembryonic antigen (CEA),whole blood neutrophils/lymphocytes (NLR) in diagnosis and differential diagnosis of small cell lung cancer (SCLC).Methods Fifty-three patients with SCLC (SCLC group),33 patients with lung adenocarcinoma (LAC) (LAC group),29 patients with lung squamous cell carcinoma (LSC) (LSC group),16 patients with gastric carcinoma (GC) (GC group),14 patients with hepatic carcinoma (HC) (HC group),13 patients with colorectal cancer (CC) (group CC),12 patients with nasopharyngeal carcinoma (NC) (NC group),and 45 healthy controls (control group) were selected.Serum MSA was detected by indirect immunofluorescence method.Serum CEA was detected by chemiluminescence.Whole blood NLR was measured by electrical impedance method.The sensitivity and specificity of single and combined detection of serum MSA,CEA and whole blood NLR were analyzed.Results Compared with the other groups,the positive rate of serum MSA in the SCLC group was high.Compared with the SCLC group,the positive rates of serum CEA and whole blood NLR in the LAC group were high,while the positive rates of CEA and whole blood NLR in the control group were lower (all P ＜ 0.05).The sensitivity of detecting NLR alone in diagnosis of SCLC was the highest (43.40％),while specificity of detecting MSA alone was the highest (96.58％).The sensitivity of combined detection of MSA + CEA + NLR in diagnosis of SCLC was the highest (in parallel,81.84％),and the specificity was the highest (in series,100.00％).MSA and CEA had higher consistency (κ =0.654),and MSA was moderately consistent with NLR (κ=0.451).Conclusion The combined detection of serum MSA,CEA,and whole blood NLR is helpful for the diagnosis and differential diagnosis of SCLC.关键词
小细胞肺癌/抗纺锤体抗体/癌胚抗原/中性粒细胞/淋巴细胞Key words
small cell lung cancer/anti-spindle antibody/carcinoembryonic antigen/neutrophils/lymphocytes分类
医药卫生引用本文复制引用
谭立明,曾婷婷,田永建,余建林,陈娟娟,李华,曹莉萍,郑葳,付慧颖,蒙仪妹,管晓琳,吴思凡,隆婷婷,王巧花,吴洋..MSA、CEA、NLR联合检测对小细胞肺癌的诊断及鉴别诊断效能[J].山东医药,2017,57(47):13-16,4.基金项目
江西省科技计划项目(20151BBI90047,20171BAB205076). （20151BBI90047,20171BAB205076）
