山东医药2017，Vol.57Issue(47)：56-59,4.DOI:10.3969/j.issn.1002-266X.2017.47.017
维持性血液透析患者贫血治疗效果的影响因素分析
Influencing factors of anemia treatment in maintenance hemodialysis patients
摘要
Abstract
Objective To analyze the influencing factors of anemia treatment in maintenance hemodialysis (MHD) patients.Methods Totally 337 cases of patients with end-stage renal disease were divided into the substandard group of 179 cases (Hb ＜ 110 g/L) and standard group of 158 cases (Hb ≥ 110 g/L) according to anemia guidelines.Single factor analysis was used to compare the clinical data of two groups,and the Multi-factor Logistic regression analysis was used to compare the influencing factors for anemia treatment.Results In the standard group,patients with diabetes accounted for 18.4％,with hemoperfusion (HP) frequency more than 2 h/month accounted for 50.6％,patients who took angiotensin converting enzyme inhibitor (ACEI)/angiotensin Ⅱ receptor antagonist (ARB) accounted for 35.4％,the high sensitive C reactive protein (hs-CRP) was (2.21 ± 3.12) mg/L,the serum phosphorus before hemodialysis was (1.93 ±0.65) mmol/L,and the serum albumin before hemodialysis was (39.76 ± 3.11) g/L,patients with transferrin saturation (TSAT) ＞0.2 accounted for 91.8％,and the single chamber urea clearance index (spKt/V) was i.38 ±0.27;in the substandard group,the above indexes were separately 27.9％,35.2％,53.1％,(3.92 ± 4.42) mg/L,(1.77 ± 0.58) mmol/L,(38.38 ±3.38) g/L,82.7％,and 1.30 ±0.29;the differences were statistically significant between these two groups (all P ＜0.05).The SpKt/V,frequency of HP,taking ACEI/ARB,TSAT,hs-CRP,and serum albumin before HD were related to anemia treatment,during which,spKt/V,frequency of HP ＞ 2 h/month,TSAT ＞ 0.2,serum albumin before HD were the protective factors for anemia treatment,and taking ACEI/ARB and hs-CRP were risk factors for anemia treatment.Conclusions Standard-reaching rate of anemia treatment in MHD patients is low.Further more,inadequate dialysis,inadequate blood perfusion,taking ACEI/ARB,iron deficiency,inflammation,and malnutrition may be the influencing factors for anemia treatment.关键词
血液透析/贫血/单室尿素清除指数/血液灌流频率/血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂/转铁蛋白饱和度/超敏C反应蛋白/血液透析前血白蛋白Key words
hemodialysis/anemia/single chamber urea clearance index/blood perfusion frequency/angiotensin converting enzyme inhibitor/angiotensin Ⅱ receptor antagonist/transferrin saturation/hypersensitive C reactive protein/serum albumin before hemodialysis分类
医药卫生引用本文复制引用
王梦平,曾炎,王明初,温向琼,吴蔚华,甘林望,秦露丹,丁静雅,刘建..维持性血液透析患者贫血治疗效果的影响因素分析[J].山东医药,2017,57(47):56-59,4.基金项目
四川省教育厅科研计划(14ZA0136). （14ZA0136）
