山西大学学报（自然科学版）2018，Vol.41Issue(2)：434-439,6.DOI:10.13451/j.cnki.shanxi.univ(nat.sci.).2018.02.027
苯并[b]荧蒽对大鼠肺泡巨噬细胞的氧化损伤效应
Toxic Effects of Benzo[b]Fluoranthene on Alveolar Macrophage
摘要
Abstract
To investigate the toxic effects of benzo[b] fluoranthene on alveolar macrophages,the rat AMs were treated with Benzo[b]-fluoranthene at different concentrations,MTT assay was carried out to evaluate the cell viability after exposure to Benzo[b]fluoranthene,moreover,the activities of antioxidant enzymes and MDA content were determined by kits following the manufacturer's instruction.The results showed that Benzo[b]fluoranthene caused the decrease of AM SOD activities and GSH content and increased MDA content in a dose-response manner,and benzo[b]fluoranthene induced ROS generation.The results suggest benzo[b]fluoranthene-induced oxidative damage may contribute to impairment of organism.关键词
苯并[b]荧蒽/巨噬细胞/毒性作用Key words
benzo[b] fluoranthene/macrophages/toxicity分类
医药卫生引用本文复制引用
张丽凤,魏海英,张云芸..苯并[b]荧蒽对大鼠肺泡巨噬细胞的氧化损伤效应[J].山西大学学报（自然科学版）,2018,41(2):434-439,6.基金项目
国家自然科学基金(21177078) （21177078）
山西自然科学基金(201601D202086) （201601D202086）
