同位素2018，Vol.31Issue(3)：143-156,14.DOI:10.7538/tws.2018.31.03.0143
99mTc-放射性药物的现状和展望
Current Status and Prospects of 99mTc-radiopharmaceuticals
摘要
Abstract
Using molecular imaging techniques,radionuclide-labeled molecular probes can provide noninvasive and real-time visualization of specific biochemical processes in the living humans and pathological process of various human diseases at the molecular level,which will pave the way to precision medicine.99mTc-radiopharmaceuticals is playing significant roles in the diagnosis of human diseases and efficacy monitoring of therapeutic strategies together with single photon emission computed tomography imaging modality.This review provided an overview of current status of 99m Tc-radio-pharmaceuticals used in clinic and clinical trials.Possible future trends in the field of 99m Tc-radiopharmaceuticals were discussed.Investigation on the new targets or new biochemical processes as targets and basic technetium chemistry including exploring novel labeling methods and novel technetium building blocks were addressed.Develop-ment on the novel 99mTc-radiopharmaceuticals with high affinity,selectivity and specific-ity for the imaging of unique targets or specific biochemical processes together with 99mTc labeling methods suitable for clinical use will accelerate the clinical translation of new 99mTc-radiopharmaceuticals.关键词
99mTc-放射性药物/SPECT/锝配位化学/诊断/治疗放射性核素对Key words
99mTc-radiopharmaceuticals/SPECT/technetium coordination chemistry/theragnostic pairs分类
医药卫生引用本文复制引用
田佳乐,贾红梅..99mTc-放射性药物的现状和展望[J].同位素,2018,31(3):143-156,14.基金项目
国家自然科学基金资助项目(21471019) （21471019）
