同位素2018，Vol.31Issue(3)：188-197,10.DOI:10.7538/tws.2018.31.03.0188
碘-124的生产、标记及在肿瘤PET分子影像的应用
Production of Iodine-124 and Its Application in PET Molecular Imaging
摘要
Abstract
Iodine-124(124I)is an isotope for positron as well as unique chemical proper-ties and convenient half-life of 4.2 days.Its modes of decay are 74.4% electron capture-and 25.6% positron emission.Until recently,124I is not considered to be an attractive isotope for medical application owing to its complex radioactive decay scheme and the high-energy gamma rays.124I can be made by numerous nuclear reactions via a cyclo-tron.The most common starting material is 124Te and 124I that can decay to 124Te.124I as sodium iodine form can be used to image the thyroid and corresponding tumor using pos-itron emission tomography(PET)directly.The 124I nuclide can be chemically bonded to a pharmaceutical to form a positron-emitting radiopharmaceutical.Radioiodination of 124I can be efficiency attached to small molecular,peptide or antibody within radiochemistry labs.Nowadays,due to the increasing application of PET in medical oncology,pharma-cokinetics and drug metabolism,124I-labeled radiopharmaceuticals are now becoming one of the most useful tools for PET imaging.124I-labeled monoclonal antibodies(mAbs) are being used for clinical immuno-PET.Among them,124I-cG250 accurately identifies clear-cell renal carcinoma attracting clinical attentions.Based on those progress,this review outlined the physical property,production and application of 124I in PET molecu-lar imaging.关键词
碘-124/正电子发射型计算机断层显像/肿瘤/分子影像/固体靶核素生产Key words
iodine-124/positron emission-computed tomography/tumor/molecular imaging/solid target nuclide production分类
能源科技引用本文复制引用
李立强,王风,刘特立,朱华,杨志..碘-124的生产、标记及在肿瘤PET分子影像的应用[J].同位素,2018,31(3):188-197,10.基金项目
国家自然科学基金项目(81501519,81571705) （81501519,81571705）
北京市卫生与计划生育委员会215人才骨干项目支持 （）
北京市科技新星项目(Z171100001117020) （Z171100001117020）
