畜牧兽医学报2018，Vol.49Issue(5)：871-878,8.DOI:10.11843/j.issn.0366-6964.2018.05.001
牛全基因组拷贝数变异研究进展
Research Progress on Genomic Copy Number Variations in Cattle
摘要
Abstract
Copy number variation (CNV),as an important component of genomic structural varia tion (SV),plays important roles in phenotypic variability,disease susceptibility estimates and species evolution.Currently,a large number of studies have been widely conducted to analyze genome-wide CNV of domestic animals using high throughput and density technologies,which enable CNV as an important molecular marker for complex traits in genome-wide association analysis study (GWAS).In addition,CNV provides a new insight into the analysis of population genetic structure.Therefore,this review comprehensively summarized definition,formation mechanism,distribution characteristics,analyzing methods,genetic effect of CNV in cattle and the CNV on bovine Y chromosome based on previous studies.Meanwhile,we also raised some problems in current CNV studies,and provide a brief outlook of the future for CNV studies,which would supply guidance for cattle genome CNV studies in the future.关键词
牛/拷贝数变异/遗传效应Key words
cattle/copy number variation/genetic effect分类
农业科技引用本文复制引用
裴生伟,王丽,曹学涛,李万宏,李发弟,乐祥鹏..牛全基因组拷贝数变异研究进展[J].畜牧兽医学报,2018,49(5):871-878,8.基金项目
国家自然科学基金(31501918) （31501918）
长江学者和创新团队发展计划(IRT13019) （IRT13019）
甘肃省农业科技创新项目(GNCX-2014-41) （GNCX-2014-41）
