畜牧兽医学报2018，Vol.49Issue(5)：879-886,8.DOI:10.11843/j.issn.0366-6964.2018.05.002
巨噬细胞-γδT细胞免疫轴在猪格拉瑟氏病发病机制中的作用
The Role of Macrophage-γδT Cell Immune Axis in the Pathogenesis of Gl(a)sser's Disease
摘要
Abstract
Haemophilus parasuis (Hps) is a major bacterial pathogen in pigs that is prevalent in many countries worldwide.It can easily parasitize the upper respiratory tract of newborn piglets through contact transmission.Under certain conditions,Hps infection leads to systematic inflammations,in which the most typical clinical symptom is the so-called Gl(a)sser's disease.Co-infections of Hps with other bacteria and/or viruses have been reported,which can impair the host protective immunity and affect the production efficiency seriously.In the last decade,Hps infection has continuously attracted scientists and great progress in the basic research fields of prevention,control,and in vivo/ in vitro challenges have been made.Whereas the molecular mecha nism of Hps and host interaction is still fuzzy that warrants further investigation.Based on our studies and results from other teams,we speculate that the “Macrophage (Mφ)-γδT cell” immune axis may play a crucial role in the pathogenesis of Gl(a)sser's disease.In order to discuss better with our academic faculties,we herein present a deep review on this hypotheses.Objectives of this article are to discuss key issues of host immune response and to discover the underlying main cellular players.We hope to provide insight for the signaling pathway studies and Hps resistant genetic marker discoveries in pigs.关键词
猪/副猪嗜血杆菌/免疫应答/巨噬细胞/γδT细胞Key words
pig/Haemophilus parasuis/immune response/macrophage/γδT cell分类
农业科技引用本文复制引用
程蕾,陈洪波..巨噬细胞-γδT细胞免疫轴在猪格拉瑟氏病发病机制中的作用[J].畜牧兽医学报,2018,49(5):879-886,8.基金项目
湖北省教育厅科学研究计划中青年人才项目(Q20161710) （Q20161710）
