西南国防医药2018，Vol.28Issue(5)：425-428,4.DOI:10.3969/j.issn.1004-0188.2018.05.010
Gli1在乳腺癌侵袭转移过程中的作用及与病理特征的关系
Role of Gli1 in breast cancer invasion and metastasis and the relation with pathological features
孟尚文 1郑建云2
作者信息
- 1. 724200 陕西勉县,勉县医院病理科
- 2. 西安医学院第一附属医院病理科
- 折叠
摘要
Abstract
Objective To explore the role of glioma-associated oncogene protein-1(Gli1) in breast cancer invasion and metastasis and the pathological significance.Methods The data of a total of 191 cases of female breast cancer treated with radical axillary lymph node dissection were retrospectively analyzed.The Glil protein immunohistochemistry in postoperative pathological specimens received chemical staining.The relation between the clinical pathological features and the expression of Glil and the correlation between the skip metastasis of lymph node and the pathological features (including the expression of Gli1).Results The positive rate of Gli1 in the 191 cases was 21.47％.In the cases with positive expression of Gli1,the positive rate of estrogen receptor (ER),BRCA1 and E-cadherin was significantly lower than that in the cases with negative expression of Glil (P ＜ 0.01).The tumor size,regional lymph node staging,TNM staging,Gli1 positive expression and breast cancer molecular typing were all correlated with lymph node metastasis.The Gli1 positive expression (OR=20.122,P ＜ 0.01) and regional lymph node staging (OR=0.312,P ＜ 0.05) were independent risk factors that affect the jump metastasis of axillary lymph node of breast cancer.Conclusion Gli1 protein is one of the independent risk factors that affect the jump metastasis of axillary lymph node of breast cancer.Its mechanism may be correlated with Gli1 protein up-regulation and ER,BRCA1 and E-cadherin protein down-regulation.关键词
乳腺癌/Gli1/病理学/侵袭/转移Key words
breast cancer/Gli1/pathology/invasion/metastasis分类
医药卫生引用本文复制引用
孟尚文,郑建云..Gli1在乳腺癌侵袭转移过程中的作用及与病理特征的关系[J].西南国防医药,2018,28(5):425-428,4.
