中国医疗设备2018，Vol.33Issue(5)：71-75,96,6.DOI:10.3969/j.issn.1674-1633.2018.05.019
DCE-MRI定量参数在前列腺病变诊断中的价值及与Gleason评分的相关性
Dignostic Value of DCE-MRI Quantitative Parameters in Prostate Disease and the Association of Gleason Score in the Pathology of Prostate Cancer
周红梅 1徐向阳 1李莹 1刘祥 1杨建 1黄德珍1
作者信息
- 1. 华中科技大学同济医学院附属梨园医院 放射科,湖北 武汉 430070
- 折叠
摘要
Abstract
Objective To explore the value of dynamic enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters in the differential diagnosis of prostate cancer and prostatic hyperplasia, and to understand the correlation between quantitative parameters and pathological Gleason score of prostate cancer. Methods A total of 156 cases (61 prostate cancer and 95 prostatic hyperplasia) were treated with DCE-MRI. The mean, standard deviation and percentile and variance analysis of the quantitative parameters were analyzed. Meanwhile, the association of quantitative parameters of DCE-MRI in prostate cancer and pathologic Gleason score was analyzed. Results Compared with the prostate hyperplasia group, the average, standard deviation, 50%, 75%, and 90% of the Ktrans, Ve and Vp in prostate cancer group were significantly higher (P<0.01) than that of benign prostate prostatic hyperplasia group. The Kep value of the prostate cancer group was significantly reduced by 10%, and the accuracy rate was the highest when the Kep value was in 10thpercentile. The sensitivity was 66.7% and the specificity was 72.7%, if the Kep value was 10% lower than that of prostate cancer. Linear correlation and regression analysis showed that the parameters of DCE-MRI in prostate cancer group were in linearly dependent on the parameters of Ktrans and Ve on Gleason's. Conclusion DCE-MRI can quantitatively reflect the distribution and perfusion of microvascular in prostate. Multiple quantitative parameters can be applied to the differential diagnosis of prostate cancer and prostatic hyperplasia, and multiple quantitative parameters have linear correlations with the Gleason's score in the pathology of prostate cancer, and can reflect the tumor grade and stage.关键词
前列腺癌/动态增强磁共振成像/定量参数/Gleason评分Key words
prostate cancer/dynamic contrast enhanced magnetic resonance imaging/quantitative parameters/Gleason's score分类
医药卫生引用本文复制引用
周红梅,徐向阳,李莹,刘祥,杨建,黄德珍..DCE-MRI定量参数在前列腺病变诊断中的价值及与Gleason评分的相关性[J].中国医疗设备,2018,33(5):71-75,96,6.
