医疗卫生装备2018，Vol.39Issue(5)：35-38,4.DOI:10.7687/j.issn1003-8868.2018.05.035
低频脉冲电磁场对大鼠应激性溃疡胃壁血液循环及超微结构的影响
Effects of low frequency pulsed electromagnetic field on stomach blood circulation and ultra microstructure of stress ulcer in rats
摘要
Abstract
Objective To determine non-thermal biological effect of low frequency pulsed electromagnetic field (LFPEF)on the stomach blood circulation and ultra microstructure of rat stress ulcer. Methods Thirty-six Sprague-Dawley rats were assigned to three equal groups:control,ulcer without interference group(UW)and ulcer exposure groups(UE).The rats stress ulcer models were constructed with the combination method of soak and bind in the low-pressure and hypoxia circumstance. Based on the singlechip,a LFPEF generator with adjustable frequency, amplitude and duty ratio was developed. Then the stomachs of the rats were exposed to the LFPEF generator 3 hours per day.On days 1,3,5 and 7,the blood circulation of the stomach was analyzed by the content of the serum NO and contrast ultrasonography.In addition,the ulcer tissue was taken out for section-staining. Finally, the pathological change of the stomach ultra microstructure was observed under a light microscope. Results On different days, the contents of the serum NO and microbubble concentration of UE group were significantly higher than those of the UW group(P<0.05). The pathological observation showed that the restoration of the gastric tissue in UE group was faster than that in the UW group(P<0.05).Conclusion LFPEF with certain proper parameter could improve the gastric tissue blood circulation and accelerate the stress ulcer restoration. [Chinese Medical Equipment Journal,2018,39(5):35-38]关键词
低频脉冲电磁场/应激性溃疡/血液循环/超微结构Key words
low frequency pulsed electromagnetic field/stress ulcer/blood circulation/ultra microstructure分类
医药卫生引用本文复制引用
焦明克,王芳利,胡劼,焦琳,张鹏..低频脉冲电磁场对大鼠应激性溃疡胃壁血液循环及超微结构的影响[J].医疗卫生装备,2018,39(5):35-38,4.基金项目
新疆维吾尔自治区自然科学基金项目(2015211C234) （2015211C234）
