中国免疫学杂志2018，Vol.34Issue(5)：723-726,731,5.DOI:10.3969/j.issn.1000-484X.2018.05.016
miR-17-92启动子区多态性在广西人群中分布及与淋巴细胞关系
Distribution of polymorphisms at promoter region of miR-17-92 in Guangxi population and association of its polymorphisms and lymphocytes
摘要
Abstract
Objective:To investigate the distribution characteristics of polymorphisms of rs9515692C/T and rs1352743A/G in the promoter region of miR-17-92 gene cluster in Guangxi people and compare them with those of other ethnic groups and explore the association of its polymorphisms and lymphocytes.Methods:The rs9515692C/T and rs1352743A/G of miR-17-92 gene cluster were genotyped by using SNaPshot technique and DNA sequencing.Detection of the number of lymphocytes using flow cytometry.The differences of polymorphisms between groups were analyzed statistically.Results:No significant differences of genotype and allele frequency in the two SNPs was observed between different gender in the Guangxi population(P>0.05).However,there were significant differences in the distribution frequencies of genotype and allele of Europeans,Japanese and Africans in rs9515692C/T and rs1352743A/G (P<0.05).Conclusion:Polymorphisms of rs9515692C/T and rs1352743A/G are different in different people.In addition,rs9515692C/T polymorphism may be associated with the number of B cells.关键词
miR-17-92/基因簇/多态性/淋巴细胞Key words
miR-17-92/Gene cluster/Polymorphism/Lymphocytes分类
生物科学引用本文复制引用
王荣,覃海媚,黄华佗,陆玉兰,郭静,蓝艳,王俊利,韦叶生..miR-17-92启动子区多态性在广西人群中分布及与淋巴细胞关系[J].中国免疫学杂志,2018,34(5):723-726,731,5.基金项目
国家自然科学基金(81560552,81260234)资助. （81560552,81260234）
