中国药理学与毒理学杂志2017，Vol.31Issue(12)：1169-1176,8.DOI:10.3867/j.issn.1000-3002.2017.12.004
小胶质细胞对缺血性脑卒中的双重作用
Dual effect of microglia on ischemic stroke: a review
摘要
Abstract
Ischemic brain injury is the main cause of high mortality,high disability and high recurrence rates in ischemic stroke.The activation and differentiation of microglia are associated with inflammatory responses of ischemic brain injury,playing an important role in the occurrence,development and outcome of ischemic stroke.In addition,there is no effective treatment for ischemic stroke.Thus,it is of clinical significance to investigate regulatory mechanisms of microglia for ischemic stroke treatment.This review introduces the dual effect of microglia on ischemic stroke and research progress in associated treatment for ischemic stroke,hoping to provide new ideas for investigating targeted intervention therapies.关键词
脑卒中/缺血性脑损伤/小胶质细胞Key words
cerebral stroke/ischemic brain injury/microglia分类
医药卫生引用本文复制引用
范丽桢,陶文渊,张曦,韩沁煜,徐运..小胶质细胞对缺血性脑卒中的双重作用[J].中国药理学与毒理学杂志,2017,31(12):1169-1176,8.基金项目
国家自然科学基金(81630028) （81630028）
江苏省医学重点项目(BE2016610) （BE2016610）
江苏省医学重点学科(ZDXKA2016020).The project supported by National Natural Science Foundation of China (81630028) （ZDXKA2016020）
Science and Technology Department of Jiangsu Province (BE2016610) （BE2016610）
and Jiangsu Province Key Medical Discipline (ZDXKA2016020) （ZDXKA2016020）
