中国医学科学院学报2018，Vol.40Issue(1)：91-97,7.DOI:10.3881/j.issn.1000-503X.2018.01.014
Wnt信号通路在胚胎着床中的作用
Contribution of Wnt Signaling Pathway to Embryo Implantation
摘要
Abstract
The establishment of the endometrial receptive state,the implantation of activated blastocysts,and the decidualization of the uterine stroma are essential conditions for successful implantation in mammals and play decisive roles for subsequent pregnancy outcomes.The Wnt signaling pathway is associated with a variety of key functions such as proliferation,differentiation,apoptosis,and regeneration.During the embryo implantation,the Wnt signaling pathway plays an indispensable role.Studies have shown that the abnormal expression of Wnt signaling pathway can lead to endometriosis,endometrial cancer,and other reproductive diseases that seriously affect human health and quality of life.In this article we summarize the roles of Wnt signaling pathway in the establishment of uterine receptivity,blastocyst activation,embryo implantation,and decidualization and its regulatory mechanisms.关键词
Wnt信号通路/围着床期/胚胎着床Key words
Wnt signaling pathway/peri-implantation/embryo implantation分类
医药卫生引用本文复制引用
唐业东,张正红,唐宗浩,王正朝..Wnt信号通路在胚胎着床中的作用[J].中国医学科学院学报,2018,40(1):91-97,7.基金项目
国家自然科学基金(31271255)、福建省自然科学基金(2016J01145)和福建省教育厅科技项目(JAT160118) Supported by the National Natural Sciences Foundation of China (31271255),the Fujian Provincial Natural Science Foundation (2016J01145),and the Fujian Provincial Science and Technology Project of the Education Department(JAT160118) （31271255）
