中国医学科学院学报2018，Vol.40Issue(1)：112-115,4.DOI:10.3881/j.issn.1000-503X.2018.01.017
自噬和凋亡在肌少症中的研究进展
Roles of Autophagy and Apoptosis in Sarcopenia
摘要
Abstract
Sarcopenia is an aged-related progressive and systemic loss of skeletal muscle mass and functions.It may be caused by factors such as exercise,nutrition,genetic factors,endocrine factors,and inflammation.The pathophysiological mechanisms include mitochondrial dysfunction,excessive activation of apoptosis,dysregulation of autophagy,abnormal function of satellite cells,and aggregation of reactive oxygen species.This article summarizes the relationships of autophagy and apoptosis with sarcopenia and discusses the values of autophagy regulation and apoptosis reduction in the management of sarcopenia.关键词
肌少症/病理生理机制/自噬/凋亡Key words
sarcopenia/pathophysiological mechanisms/autophagy/apoptosis分类
医药卫生引用本文复制引用
贡歌,杨翔,殷建,张兴虎,张瑗,万文辉..自噬和凋亡在肌少症中的研究进展[J].中国医学科学院学报,2018,40(1):112-115,4.基金项目
全军保健专项基金(13BJZ11)、南京军区医学卫生科研基金(11MA101)和中国人民解放军南京总医院院管课题(2017065) Supported by the Special Fund for Military Health(13BJZ11),the Nanjing Military Command Medical Research Foundation(11MA101),and the Hospital Project of the Nanjing General Hospital of PLA (2017065) （13BJZ11）
