中国真菌学杂志2018，Vol.13Issue(2)：79-82,4.
白念珠菌酵母相与菌丝相对5种抗真菌药物的敏感性比较
Susceptibility of Candida albicans to 5 antifungal agents: comparison of yeast and hyphal forms
摘要
Abstract
Objective To compare the susceptibility of yeast and hyphal forms of Candida albicans to commonly used antifungal agents,so that to provide theoretical guidance for the pathogenic mycology research and clinical medication.Methods Susceptibility of 220 clinical isolates of Candida albicans to antifungal agents was determined using ATB Fungus 3 Kits (bioMerieux,France).Results The susceptibility rates of yeast and hyphal forms to amphotericin B,fluconazole,itraconazole,voriconazole and 5-fluorocytosine were 97.27％ vs 97.73％,81.82％ vs 85％,87.27％ vs 90.46％,92.72％ vs 95％,96.82％vs 97.27％ respectively.MICs to fluconazole,itraconazole,voriconazole of yeast forms were higher than those of hyphal forms (P＜0.05),No satistically difference was found to amphotericin B (P ＞0.05).The overall sensitivity of two tested forms to 5 antifungal agents was 85.46％ (188/220).32 yeast strains showed resistance and intermediation,but hyphal strains showed intermediation and sensitivity.Conclusion There were differences between the susceptibility of yeast and hyphal forms of Candidia albicans to antifungal agents.The antifungal activity of hyphal-form was higher than that of yeast-form.关键词
白念珠菌/酵母相/菌丝相/敏感性Key words
Candida albicans/yeast-form/hyphal-form/susceptibility分类
医药卫生引用本文复制引用
厉荣玉,陈京,欧成举..白念珠菌酵母相与菌丝相对5种抗真菌药物的敏感性比较[J].中国真菌学杂志,2018,13(2):79-82,4.基金项目
安徽省高校省级自然科学研究资助项目(KJ2011B201) （KJ2011B201）
