中国卒中杂志2018，Vol.13Issue(4)：311-316,6.DOI:10.3969/j.issn.1673-5765.2018.04.004
高血糖对糖尿病与非糖尿病患者前循环取栓预后的影响研究
Study on the Prognostic Effect of Hyperglycemia in Diabetic and Non-diabetic Patients Treated with Mechanical Thrombectomy
汪玲 1白永杰 1资文杰 1徐格林1
作者信息
- 1. 210002 南京 南京军区南京总医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the prognostic value of hyperglycemia between diabetic and non-diabetic patients with acute ischemic stroke who received anterior circulation mechanical thrombectomy. Methods Patients included in this analysis were those who were enrolled in Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke Registry (ACTUAL) study and whose glucose level were >8.6 mmol/L. Patients were divided into diabetes and non-diabetes group according to the diagnosis based on diabetic history and admission glycosylated hemoglobin (HbAlc). The poor functional outcomes were defined as modified Rankin Scale (mRS) score 3-6 at 90 d after onset. Results A total of 160 patients whose glucose level were >8.6 mmol/L were included in this study, among which, 82 (51.2%) patients were diabetes and 78 (48.8%) patients were non-diabetes. A total of 114 (71.3%) patients had poor functional outcomes. Non-diabetic patients were more likely to reach poor functional outcomes(83.3% vs 59.8%,P=0.001).After adjusted for confounders including arthrosclerosis cardiac artery disease, hypertension, percentage of lymphocytes in neutrophils, National Institutes Of Health Stroke Scale (NIHSS) score, pucture-blood revascularization and blood glucose on admission, the multivariable logistic regression analysis showed that non-diabetes hyperglycemia still had a high risk of poor functional outcomes than diabetes [odds ratio (OR)=4.2, 95% confidence interval (CI) 1.52-11.56, P=0.006]. Conclusion The deleterious influence of hyperglycemia is more prominent in non-diabetic patients after received mechanical thrombectomy.关键词
高血糖/机械取栓/糖尿病/预后Key words
Hyperglycemia/Mechanical thrombectomy/Diabetes/Prognosis引用本文复制引用
汪玲,白永杰,资文杰,徐格林..高血糖对糖尿病与非糖尿病患者前循环取栓预后的影响研究[J].中国卒中杂志,2018,13(4):311-316,6.
