中国卒中杂志2018，Vol.13Issue(4)：317-321,5.DOI:10.3969/j.issn.1673-5765.2018.04.005
高龄急性轻型缺血性卒中早期阿替普酶静脉溶栓疗效观察
Observation of the Effect of Alteplase Intravenous Thrombolysis in the Early Stage of Acute Mild Ischemic Stroke in the Elderly
摘要
Abstract
Objective To investigate the efficacy and safety of alteplase intravenous thrombolytic therapy within 3 hours after onset of mild ischemic stroke in the elderly. Methods In our hospital from October 2015 to October 2017, 48 elderly patients with acute mild ischemic stroke who were admitted into our hospital consecutively within 3 hours after onset were randomly divided into two groups: 24 patients in the intravenous thrombolysis group and 24 patients in the non-thrombolysis group. The general condition, baseline National Institute of Health Stroke Scale (NHISS) scores, intracranial hemorrhage conversion rates after 24 hours of treatment, modified Rankin Scale (mRS) score after 90 days of treatment, and 90-day mortality were compared between the two groups on admission. Results There were no significant difference in general clinical data and baseline NIHSS score between the intravenous thrombolytic group and the non-thrombolysis group. In the intravenous thrombolytic group and the non-thrombolysis group, the conversion rate of intracranial hemorrhage after 24 hours was 4.17% and 0 (P=1.000). The 90-day mortality of two groups was 4.17% (P=1.000). The ratio of 90-day mRS score of 0-2 in the intravenous thrombolytic group and the non-thrombolysis group was 83.33% and 54.17% (P=0.029). Conclusion Early alteplase intravenous thrombolysis in elderly patients with acute ischemic stroke does not increase the risk of acute intracranial hemorrhage, it can significantly improve the prognosis of elderly patients with mild ischemic stroke, without increasing the mortality.关键词
急性轻型缺血性卒中/静脉溶栓/阿替普酶Key words
Acutmilischemic stroke/Intravenouthrombolysis/Alteplase引用本文复制引用
杨江胜,朱祖福,高志强,陆强彬,周国庆,方琪..高龄急性轻型缺血性卒中早期阿替普酶静脉溶栓疗效观察[J].中国卒中杂志,2018,13(4):317-321,5.基金项目
江阴市科技局[科技创新资金]社会发展科技示范项目(JYKJ3248) （JYKJ3248）
