中国卒中杂志2018，Vol.13Issue(4)：339-343,5.DOI:10.3969/j.issn.1673-5765.2018.04.009
群多普利对大鼠脑缺血再灌注损伤的保护作用研究
Neuroprotective Effects of Trandolapril on Rat Cerebral Ischemia-reperfusion Injury
周刚 1王佳君1
作者信息
- 1. 438000 黄冈 黄冈市中心医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the neuroprotective effect of Trandolapril on cerebral ischemia-reperfusion injury, and explore its possible mechanism. Methods The model of focal ischemic reperfusion in Sprague-dawley (SD) rats was prepared by middle cerebral artery occlusion (MACO) with a nylon monofilament suture. Adult male SD rats were divided randomly into sham operation group, model group, and Trandolapril treatment groups (low dosage 5 mg/kg, high dosage 10 mg/kg). The changes of neurological function scores, the cerebral infarction volumes, interleukin (IL)-1β and IL-10 content in the brain were observed. Results Compared with the sham group, integrals of neurologic defect degree, infarction volume and the IL-1β and IL-10 content in the brain of the model group were significant increased (P<0.05). Compared with the model group, treatment with Trandolapril (5 mg/kg and 10 mg/kg) lowered the integrals of neurologic defect degree and reduced the cerebral infarction volumes. Trandolapril (5 mg/kg and 10 mg/kg) could significantly reduce the content of IL-1β (P<0.05), and Trandolapril (10 mg/kg) could significantly increase the content of IL-10. Conclusion Trandolapril could alleviate cerebral ischemia reperfusion injury by regulating the expression of the pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines.关键词
大脑中动脉阻塞/群多普利/白介素/神经保护Key words
Middlcerebral arterocclusion/Trandolapril/Interleukin/Neuroprotection引用本文复制引用
周刚,王佳君..群多普利对大鼠脑缺血再灌注损伤的保护作用研究[J].中国卒中杂志,2018,13(4):339-343,5.
