中成药2018，Vol.40Issue(5)：1060-1064,5.DOI:10.3969/j.issn.1001-1528.2018.05.010
鱼腥草挥发油HPCD包合物肠用温敏凝胶的制备
Preparation of thermosensitive intestinal gels of Houttuynia cordata volatile oils HPCD inclusion compound
摘要
Abstract
AIM To prepare the thermosensitive intestinal gels of Houttuynia cordata Thunb volatile oils hydroxypropyl-β-cyclodextrin (HPCD) inclusion compound.METHODS For the gels prepared by cold dissolving method,poloxamer 407 consumption and poloxamer 188 consumption were taken as influencing factors,together with phase transition temperature as an evaluation index,central composite design-response surface method was applied to optimizing the formulation.With 2-undecanone as an index component,the gels' dissolution rate and in vitro release rate were investigated by non-membrane dissolution method and dialysis bag method respectively,whose stability was then evaluated by high temperature (40,60 ℃),low temperature (4 ℃),strong light [(4 500 ±500) 1x] and acceleration (three months) tests.RESULTS The optimal conditions were determined to be 20.61％ for P407 consumption and 3.03％ for P188 consumption,the phase transition temperature was 36.5 ℃.Within the time range of 30-150 min,the HPCD inclusion compound gels exhibited higher accumulative dissolution rate than the volatile oils gels,which tended to be consistent in 150-210 min,but the former exhibited higher accmulative release rate (0-50 h) than the latter all the time.The obtained gels showed good stability at low temperature,whose appearance,characteristic (except for high temperature) and pH were stable at high temperature,strong light and acceleration with obviously decreased 2-undecanone content.CONCLUSION The thermosensitive intestinal gels of Houttuynia cordata Thunb volatile oils HPCD inclusion compound should be stored at low temperature (4 ℃).关键词
鱼腥草挥发油/HPCD包合物/肠用温敏凝胶/甲基正壬酮/星点设计-效应面法/冷溶法Key words
Houttuynia cordata Thunb volatile oils/HPCD inclusion compound/thermosensitive intestinal gels/2-undecanone/central composite design-response surface method/cold dissolving method分类
医药卫生引用本文复制引用
张壮丽,赵晓丹,王纪芬,赵志鸿,张小俊,王桂芳..鱼腥草挥发油HPCD包合物肠用温敏凝胶的制备[J].中成药,2018,40(5):1060-1064,5.基金项目
河南省高等学校重点科研项目资助计划(18A360005) （18A360005）
河南省医药科学研究院基本业务费科研项目(YYYJK201710) （YYYJK201710）
