中成药2018，Vol.40Issue(5)：1065-1069,5.DOI:10.3969/j.issn.1001-1528.2018.05.011
3种水提预处理方法对白芷总香豆素提取物的影响
Effects of three aqueous extraction preprocessing methods on total coumarins extract of Angelicae dahuricae Radix
摘要
Abstract
AIM To investigate the effects of aqueous extraction at normal temperature,40 ℃,and water boiling on total coumarins extract of Angelicae dahuricae Radix.METHODS For the extracts Ⅰ-Ⅳ obtained by ethanol reflux extraction and three aqueous extraction preprocessing methods,respectively,UV and HPLC were adopted in the content determination of total coumarins and imperatorin,then the powder properties and dissolution rates were compared.RESULTS The contents of total coumarins in four extracts were 3.98％,6.03％,6.81％ and 4.46％,while those of imperatorin were 0.633％,0.540％,0.465％ and 0.155％,respectively.The angles of repose were 48.455°,42.587°,42.689° and 42.024° with the bulk densities of 0.214,0.324,0.316 and 0.354 g/cm3,respectively.Within 100 min,extract Ⅰ demonstrated higher moisture adsorption rate and equilibrium moisture absorption content than the other three extracts.The accumulative dissolution rates of various extracts were much higher than that of medicinal material fine powder within 120 min.CONCLUSION All the three aqueous extraction preprocessing methods can obviously improve the powder properties of total coumarins extract of A.dahuricae Radix and increase the dissolution rate of medicinal material fine powder.关键词
白芷总香豆素提取物/水提取预处理方法/总香豆素/欧前胡素/粉体学性质/溶出度Key words
total coumarins extract of Angelicae dahuricae Radix/aqueous extraction preprocessing methods/total coumarins/imperatorin/powder properties/dissolution rates分类
医药卫生引用本文复制引用
常金花,李云,刘翠哲..3种水提预处理方法对白芷总香豆素提取物的影响[J].中成药,2018,40(5):1065-1069,5.基金项目
河北省高校重点学科建设项目(冀教高[2013]4) （冀教高[2013]4）
