肿瘤防治研究2018，Vol.45Issue(4)：242-246,5.DOI:10.3971/j.issn.1000-8578.2018.17.0884
肿瘤相关脂肪微环境与肿瘤的恶性发展
Tumor-associated Adipose Tissue Microenvironment Supports Tumor Progression
摘要
Abstract
The peritumoral adipose tissue makes an intricate crosstalk with tumor cells and also plays a key role in tumor proliferation,invasion and metastasis because it provides hormones,adipokines and fatty acids to tumor cells.With the development and progression of the tumor,the peritumoral adipose tissue exhibits abundant and intricate changes on the basis of original construction and function.In this review,by newly defining the tumor-associated adipose tissue microenvironment,we summarized the structure,characters and the possible inducements of the tumor-associated adipose tissue microenvironment.Based on the analysis above,we further discussed the potential roles of the tumor-associated adipose tissue microenvironment in the progression of different tumor types,to provide theoretical support for the development of new drugs targeting the peritumoral adipose tissue microenvironment and clinical application of these potential agents.关键词
肿瘤相关脂肪微环境/脂肪细胞/乳腺癌/雌激素Key words
Tumor-associated adipose tissue microenvironment/Adipocyte/Breast cancer/Estrogen分类
医药卫生引用本文复制引用
李思憬,卫晓慧,何进勇,袁胜涛,孙立..肿瘤相关脂肪微环境与肿瘤的恶性发展[J].肿瘤防治研究,2018,45(4):242-246,5.基金项目
国家自然科学基金(81573456) （81573456）
