中山大学学报（医学科学版）2018，Vol.39Issue(3)：369-376,8.
40岁以上人群甲状腺结节与代谢指标之间的关联性
Association between Prevalence of Thyroid Nodule and Metabolic Parameters in Population over 40
摘要
Abstract
[Objective] The aim of our study is to examine nodule prevalence in a population over 40 years old in order to explore the relation between prevalence of thyroid nodules and metabolic parameters.[Methods] A total of 1875 individuals who were over 40 years of age were received the questionnaire and underwent thyroid ultrasonography examinations.Height,weight,waist circumference,blood pressure were measured.Levels of fasting blood glucose,fasting serum insulin,glycated hemoglobin,blood lipids,thyroid stimulating hormone and free T4 were detected.Body mass index (BMI) and homeostasis model assessment-insulin resistance (HOMA-IR) were calculated.[Result] The study included a total of 1875 subjects (513 men and 1362 women).The age of subjects were between 41 and 113 years old,and the mean age was 57.4±7.1 years old.The prevalence of thyroid nodules was 51.2％,and the prevalence of thyroid nodules in women was significantly higher than that in men (53.4％ vs.45.2％,P=0.002).The prevalence of thyroid nodules was significantly higher in subjects with hypertriglyceridemia (59.2％ vs.49.5％,P=0.009) and hypertension (56.5％ vs.47.8％,P＜ 0.001).Result of multivariate binary logistic regression revealed that hypertension (OR=1.405,P=0.002),female sex (OR=1.490,P=0.001),older age (OR=1.028,P＜0.001),and hypertriglyceridemia (OR=1.589,P=0.005) were independent risk factors for thyroid nodules.The prevalence of thyroid nodules increased along with age,systolic blood pressure and serum triglyceride level.[Conclusion] The prevalence of thyroid nodules and metabolism-related diseases were high in population over 40 years old.After adjusted for age and sex,hypertriglyceridemia and hypertension were possible independent risk factors for thyroid nodules especially in women.In general,hypertriglyceridemia and hypertension might play an important role in the pathological process of thyroid nodules.关键词
甲状腺结节/甘油三酯/高血压Key words
thyroid nodule/triglyceride/hypertension分类
医药卫生引用本文复制引用
陈晓韵,徐明彤,林刁珠,黎锋,任萌,吴木潮,张锦,王晓艺,严励..40岁以上人群甲状腺结节与代谢指标之间的关联性[J].中山大学学报（医学科学版）,2018,39(3):369-376,8.基金项目
国家自然科学基金(81270915) （81270915）
广东省科技计划项目(2014A020212114) （2014A020212114）
